Literature DB >> 18972522

Cyclic peptides from Oldenlandia affinis DC. Molecular and biological properties.

Lorents Gran1, Knut Sletten1, Lars Skjeldal2.   

Abstract

A new isolation procedure for Kalata polypeptides from the tropical plant Oldenlandia affinis DC is described. Fractions were screened by thin-layer chromatography, and Van Urk positive fractions were tested for oxytocic activity in estrogenized rat uteri. By using this procedure, we were able to isolate and characterize three macrocyclic polypeptides with uterine activity. Their amino acid sequence and biological effects have been analyzed, and their NMR spectra were compared with those of the earlier ones. All three peptides showed hemolytic activity on human blood, and were tested for antibiotic effect against E. coli, Staphylococcus aureus, and Hemophilus influenzae.

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Year:  2008        PMID： 18972522     DOI： 10.1002/cbdv.200890184

Source DB:  PubMed          Journal:  Chem Biodivers        ISSN： 1612-1872            Impact factor:   2.745


  17 in total

1.  Do plant cyclotides have potential as immunosuppressant peptides?

Authors:  Carsten Gründemann; Johannes Koehbach; Roman Huber; Christian W Gruber
Journal:  J Nat Prod       Date:  2012-01-24       Impact factor: 4.050

Review 2.  Plant cystine-knot peptides: pharmacological perspectives.

Authors:  Barbara Molesini; Davide Treggiari; Andrea Dalbeni; Pietro Minuz; Tiziana Pandolfini
Journal:  Br J Clin Pharmacol       Date:  2016-04-22       Impact factor: 4.335

Review 3.  Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors.

Authors:  Christian W Gruber; Markus Muttenthaler; Michael Freissmuth
Journal:  Curr Pharm Des       Date:  2010       Impact factor: 3.116

Review 4.  Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery.

Authors:  Andrew Gould; Yanbin Ji; Teshome L Aboye; Julio A Camarero
Journal:  Curr Pharm Des       Date:  2011-12       Impact factor: 3.116

Review 5.  NMR and protein structure in drug design: application to cyclotides and conotoxins.

Authors:  Norelle L Daly; K Johan Rosengren; Sónia Troeira Henriques; David J Craik
Journal:  Eur Biophys J       Date:  2011-02-03       Impact factor: 1.733

Review 6.  Uterotonic plants and their bioactive constituents.

Authors:  Christian W Gruber; Margaret O'Brien
Journal:  Planta Med       Date:  2010-09-15       Impact factor: 3.352

Review 7.  Biological activities of natural and engineered cyclotides, a novel molecular scaffold for peptide-based therapeutics.

Authors:  Angie E Garcia; Julio A Camarero
Journal:  Curr Mol Pharmacol       Date:  2010-11       Impact factor: 3.339

8.  Pharmacokinetically stabilized cystine knot peptides that bind alpha-v-beta-6 integrin with single-digit nanomolar affinities for detection of pancreatic cancer.

Authors:  Richard H Kimura; Robert Teed; Benjamin J Hackel; Marybeth A Pysz; Courtney Z Chuang; Ataya Sathirachinda; Jürgen K Willmann; Sanjiv S Gambhir
Journal:  Clin Cancer Res       Date:  2011-12-15       Impact factor: 12.531

9.  Cyclotide discovery in Gentianales revisited--identification and characterization of cyclic cystine-knot peptides and their phylogenetic distribution in Rubiaceae plants.

Authors:  Johannes Koehbach; Alfred F Attah; Andreas Berger; Roland Hellinger; Toni M Kutchan; Eric J Carpenter; Megan Rolf; Mubo A Sonibare; Jones O Moody; Gane Ka-Shu Wong; Steven Dessein; Harald Greger; Christian W Gruber
Journal:  Biopolymers       Date:  2013-09       Impact factor: 2.505

Review 10.  Cyclotides: macrocyclic peptides with applications in drug design and agriculture.

Authors:  David J Craik; Joshua S Mylne; Norelle L Daly
Journal:  Cell Mol Life Sci       Date:  2009-10-01       Impact factor: 9.261
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