Mean centering of ratio spectra as a new spectrophotometric method for the analysis of binary and ternary mixtures.

In this paper a new and very simple method was developed for the simultaneous determination of binary and ternary mixtures, without prior separation steps. This method is based on the mean centering of ratio spectra. The mathematical explanation of the procedure is illustrated. After modeling procedure, the method has been successfully applied to the simultaneous analysis of binary mixtures of mefnamic acid and paracetamol and ternary mixtures of acetylsalysilic acid, ascorbic acid and paracetamol. The analytical characteristics of the method such as detection limit, accuracy, precision, relative standard deviation (R.S.D.) and relative standard error (R.S.E.) was calculated. The results showed that the proposed method is simple, rapid, accurate and precise method for analysis of binary and ternary mixtures.