The utilization of copper(II) phosphate for the anodic stripping voltammetric assay of alendronate sodium, desferrioxamine mesylate and lisinopril.

A sensitive differential pulse anodic stripping voltammetric method is described for the determination of alendronate sodium, desferrioxamine mesylate and lisinopril. The procedure is based on the formation of labile drug-copper(II) complex when shaking with copper(II) phosphate suspension. The voltammetric peaks, which correspond to the reduction of the copper(II) moiety of the formed complexes are obtained at -153, -74 and -111 mV, respectively. The different experimental parameters have been carefully studied. The method has been fully validated. The limit of detection was as low as 8.6 ng ml(-1). The method has been applied successfully for the determination of the drugs in plasma and in their pharmaceutical preparations. The obtained results were compared statistically with those obtained from a published method, in case of AS, or the official USP methods, for the other two drugs.