Literature DB >> 18959740

Natural polyphenols as proteasome modulators and their role as anti-cancer compounds.

Laura Bonfili1, Valentina Cecarini, Manila Amici, Massimiliano Cuccioloni, Mauro Angeletti, Jeffrey N Keller, Anna M Eleuteri.   

Abstract

The purpose of this review is to discuss the effect of natural antioxidant compounds as modulators of the 20S proteasome, a multi-enzymatic multi-catalytic complex present in the cytoplasm and nucleus of eukaryotic cells and involved in several cellular activities such as cell-cycle progression, proliferation and the degradation of oxidized and damaged proteins. From this perspective, proteasome inhibition is a promising approach to anticancer therapy and such natural antioxidant effectors can be considered as potential relevant adjuvants and pharmacological models in the study of new drugs.

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Year:  2008        PMID： 18959740     DOI： 10.1111/j.1742-4658.2008.06696.x

Source DB:  PubMed          Journal:  FEBS J        ISSN： 1742-464X            Impact factor:   5.542


  17 in total

1.  α,β-Unsaturated carbonyl system of chalcone-based derivatives is responsible for broad inhibition of proteasomal activity and preferential killing of human papilloma virus (HPV) positive cervical cancer cells.

Authors:  Martina Bazzaro; Ravi K Anchoori; Mohana Krishna R Mudiam; Olga Issaenko; Srinivas Kumar; Balasubramanyam Karanam; Zhenhua Lin; Rachel Isaksson Vogel; Riccardo Gavioli; Federica Destro; Valeria Ferretti; Richard B S Roden; Saeed R Khan
Journal:  J Med Chem       Date:  2010-12-27       Impact factor: 7.446

2.  Protective effects of flavonoids against oxidative stress induced by simulated microgravity in SH-SY5Y cells.

Authors:  Lina Qu; Hailong Chen; Xinmin Liu; Lei Bi; Jianghui Xiong; Zebin Mao; Yinghui Li
Journal:  Neurochem Res       Date:  2010-06-23       Impact factor: 3.996

3.  The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges.

Authors:  G R Tundo; D Sbardella; A M Santoro; A Coletta; F Oddone; G Grasso; D Milardi; P M Lacal; S Marini; R Purrello; G Graziani; M Coletta
Journal:  Pharmacol Ther       Date:  2020-05-19       Impact factor: 12.310

4.  Ultra-low flow liquid chromatography assay with ultraviolet (UV) detection for piperine quantitation in human plasma.

Authors:  Madhuri Kakarala; Shiv Kumar Dubey; Malloree Tarnowski; Connie Cheng; Samadhi Liyanage; Terrence Strawder; Karim Tazi; Ananda Sen; Zora Djuric; Dean E Brenner
Journal:  J Agric Food Chem       Date:  2010-06-09       Impact factor: 5.279

Review 5.  Green tea polyphenols as proteasome inhibitors: implication in chemoprevention.

Authors:  H Yang; K Landis-Piwowar; T H Chan; Q P Dou
Journal:  Curr Cancer Drug Targets       Date:  2011-03       Impact factor: 3.428

Review 6.  Applications of Friedel-Crafts reactions in total synthesis of natural products.

Authors:  Majid M Heravi; Vahideh Zadsirjan; Pegah Saedi; Tayebeh Momeni
Journal:  RSC Adv       Date:  2018-12-03       Impact factor: 4.036

Review 7.  Natural compounds as anticancer agents: Experimental evidence.

Authors:  Jiao Wang; Yang-Fu Jiang
Journal:  World J Exp Med       Date:  2012-06-20

8.  Screening of crude plant extracts with anti-obesity activity.

Authors:  Changhyun Roh; Uhee Jung
Journal:  Int J Mol Sci       Date:  2012-02-06       Impact factor: 6.208

9.  The anticancer flavonoid chrysin induces the unfolded protein response in hepatoma cells.

Authors:  Xiangming Sun; Xiaodong Huo; Ting Luo; Minjing Li; Yancun Yin; Yangfu Jiang
Journal:  J Cell Mol Med       Date:  2011-11       Impact factor: 5.310

10.  Flavan-3-ol Microbial Metabolites Modulate Proteolysis in Neuronal Cells Reducing Amyloid-beta (1-42) Levels.

Authors:  Valentina Cecarini; Massimiliano Cuccioloni; Yadong Zheng; Laura Bonfili; Chunmei Gong; Mauro Angeletti; Pedro Mena; Daniele Del Rio; Anna Maria Eleuteri
Journal:  Mol Nutr Food Res       Date:  2021-08-07       Impact factor: 6.575
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