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Literature DB >> 18957235

Signal transduction: turning a switch into a rheostat.

Abstract

MAP kinase cascades are inherently switch-like, but, during yeast mating, MAPK signaling is graded. A new study suggests that the Ste5 scaffold protein is responsible for making this switch less switch-like.

Entities: Chemical Gene Species

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Year: 2008 PMID： 18957235 PMCID： PMC3017499 DOI： 10.1016/j.cub.2008.07.082

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

17 in total

1. Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties.

Authors: A Levchenko; J Bruck; P W Sternberg
Journal: Proc Natl Acad Sci U S A Date: 2000-05-23 Impact factor: 11.205

2. Graded mode of transcriptional induction in yeast pheromone signalling revealed by single-cell analysis.

Authors: M A Poritz; S Malmstrom; M K Kim; P J Rossmeissl; A Kamb
Journal: Yeast Date: 2001-10 Impact factor: 3.239

3. Mitogen-activated protein kinases with distinct requirements for Ste5 scaffolding influence signaling specificity in Saccharomyces cerevisiae.

Authors: Laura J Flatauer; Sheena F Zadeh; Lee Bardwell
Journal: Mol Cell Biol Date: 2005-03 Impact factor: 4.272

Signal transduction: turning a switch into a rheostat.

1. Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties.

2. Graded mode of transcriptional induction in yeast pheromone signalling revealed by single-cell analysis.

3. Mitogen-activated protein kinases with distinct requirements for Ste5 scaffolding influence signaling specificity in Saccharomyces cerevisiae.

4. Multisite protein phosphorylation makes a good threshold but can be a poor switch.

5. Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics.

6. The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes.

7. Graded mitogen-activated protein kinase activity precedes switch-like c-Fos induction in mammalian cells.

8. MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast.

9. Membrane localization of scaffold proteins promotes graded signaling in the yeast MAP kinase cascade.

10. Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5.

1. A combination of multisite phosphorylation and substrate sequestration produces switchlike responses.

2. Protein scaffolds can enhance the bistability of multisite phosphorylation systems.

3. MAPK feedback encodes a switch and timer for tunable stress adaptation in yeast.

Review 4. Stimulus-specific responses in innate immunity: Multilayered regulatory circuits.

5. Differential modulation of TCF/LEF-1 activity by the soluble LRP6-ICD.

6. Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis.