PURPOSE: A multi-centre IARC-coordinated European cohort study provided evidence of an association between lung cancer risk and bitumen fume exposure. Sensitivity analyses were conducted to assess whether these associations were robust to assumptions in the exposure assessment for which support could not be obtained due to lack of either measurements or direct observations. METHODS: New exposure estimates were generated by changing assumptions on exposure levels, specific tasks, lags, and coal tar use. Subsequently, Poisson regression models estimated relative risks (RRs); change in fit of models was evaluated. RESULTS: The influence of these assumptions was minimal, with log-likelihood deviations between -5.0 and 4.7% and similar patterns in dose-dependent increases of lung cancer risk. In the highest exposure categories, point estimates of RRs ranged 2.07-2.83 for average, and 1.22-2.23 for cumulative exposure. CONCLUSIONS: The small increase in lung cancer risk associated with bitumen fume exposure depends only to a limited extent on the subjective judgments made in the exposure assessment for this cohort.
PURPOSE: A multi-centre IARC-coordinated European cohort study provided evidence of an association between lung cancer risk and bitumen fume exposure. Sensitivity analyses were conducted to assess whether these associations were robust to assumptions in the exposure assessment for which support could not be obtained due to lack of either measurements or direct observations. METHODS: New exposure estimates were generated by changing assumptions on exposure levels, specific tasks, lags, and coal tar use. Subsequently, Poisson regression models estimated relative risks (RRs); change in fit of models was evaluated. RESULTS: The influence of these assumptions was minimal, with log-likelihood deviations between -5.0 and 4.7% and similar patterns in dose-dependent increases of lung cancer risk. In the highest exposure categories, point estimates of RRs ranged 2.07-2.83 for average, and 1.22-2.23 for cumulative exposure. CONCLUSIONS: The small increase in lung cancer risk associated with bitumen fume exposure depends only to a limited extent on the subjective judgments made in the exposure assessment for this cohort.
Authors: Igor Burstyn; Paolo Boffetta; Timo Kauppinen; Pirjo Heikkilä; Ole Svane; Timo Partanen; Isabelle Stücker; Rainer Frentzel-Beyme; Wolfgang Ahrens; Hiltrud Merzenich; Dick Heederik; Mariëtte Hooiveld; Sverre Langård; Britt G Randem; Bengt Järvholm; Ingvar Bergdahl; Judith Shaham; Joseph Ribak; Hans Kromhout Journal: Am J Ind Med Date: 2003-01 Impact factor: 2.214
Authors: Igor Burstyn; Paolo Boffetta; Timo Kauppinen; Pirjo Heikkilä; Ole Svane; Timo Partanen; Isabelle Stücker; Rainer Frentzel-Beyme; Wolfgang Ahrens; Hiltrud Merzenich; Dick Heederik; Mariette Hooiveld; Bert Brunekreef; Sverre Langård; Britt G Randem; Bengt Järvholm; Ingvar A Bergdahl; Judith Shaham; Gilles Ferro; Hans Kromhout Journal: Am J Ind Med Date: 2003-01 Impact factor: 2.214
Authors: Paolo Boffetta; Igor Burstyn; Timo Partanen; Hans Kromhout; Ole Svane; Sverre Langård; Bengt Järvholm; Rainer Frentzel-Beyme; Timo Kauppinen; Isabelle Stücker; Judith Shaham; Dick Heederik; Wolfgang Ahrens; Ingvar A Bergdahl; Sylvie Cenée; Gilles Ferro; Pirjo Heikkilä; Mariëtte Hooiveld; Christoffer Johansen; Britt G Randem; Walter Schill Journal: Am J Ind Med Date: 2003-01 Impact factor: 2.214
Authors: Ann Olsson; Hans Kromhout; Michela Agostini; Johnni Hansen; Christina Funch Lassen; Christoffer Johansen; Kristina Kjaerheim; Sverre Langård; Isabelle Stücker; Wolfgang Ahrens; Thomas Behrens; Marja-Liisa Lindbohm; Pirjo Heikkilä; Dick Heederik; Lützen Portengen; Judith Shaham; Gilles Ferro; Frank de Vocht; Igor Burstyn; Paolo Boffetta Journal: Environ Health Perspect Date: 2010-06-09 Impact factor: 9.031
Authors: Mira Hidajat; Damien Martin McElvenny; William Mueller; Peter Ritchie; John W Cherrie; Andrew Darnton; Raymond M Agius; Hans Kromhout; Frank de Vocht Journal: Occup Environ Med Date: 2019-02-16 Impact factor: 4.402