BACKGROUND: We compared performance of different exposure assessment approaches in a cohort study of cancer risk among European asphalt workers. METHODS: Three bitumen fume exposure indices (duration of exposure (years), average exposure (mg/m3) and cumulative exposure (mg/m3*years)) and two latency models (with and without a 15 year lag) were considered for an association between lung cancer mortality and bitumen fume. RESULTS: There was no association between lung cancer risk and either duration or cumulative exposure. However, there was the suggestion of an increase in lung cancer risk accompanying rise in average exposure. Only models with average bitumen fume exposure (with or without lag) improved model fit, albeit to the same extent. CONCLUSIONS: Constructing quantitative indices of exposure intensity was justified because they produced the greatest improvement in fit of models that explored possible relationship between bitumen fume exposure and lung cancer risk. The identified associations require further investigation. Copyright 2003 Wiley-Liss, Inc.
BACKGROUND: We compared performance of different exposure assessment approaches in a cohort study of cancer risk among European asphalt workers. METHODS: Three bitumen fume exposure indices (duration of exposure (years), average exposure (mg/m3) and cumulative exposure (mg/m3*years)) and two latency models (with and without a 15 year lag) were considered for an association between lung cancer mortality and bitumen fume. RESULTS: There was no association between lung cancer risk and either duration or cumulative exposure. However, there was the suggestion of an increase in lung cancer risk accompanying rise in average exposure. Only models with average bitumen fume exposure (with or without lag) improved model fit, albeit to the same extent. CONCLUSIONS: Constructing quantitative indices of exposure intensity was justified because they produced the greatest improvement in fit of models that explored possible relationship between bitumen fume exposure and lung cancer risk. The identified associations require further investigation. Copyright 2003 Wiley-Liss, Inc.
Authors: Susan Peters; Hans Kromhout; Lützen Portengen; Ann Olsson; Benjamin Kendzia; Raymond Vincent; Barbara Savary; Jérôme Lavoué; Domenico Cavallo; Andrea Cattaneo; Dario Mirabelli; Nils Plato; Joelle Fevotte; Beate Pesch; Thomas Brüning; Kurt Straif; Roel Vermeulen Journal: Ann Occup Hyg Date: 2012-07-17
Authors: Frank de Vocht; Igor Burstyn; Gilles Ferro; Ann Olsson; Mia Hashibe; Hans Kromhout; Paolo Boffetta Journal: Int Arch Occup Environ Health Date: 2008-10-28 Impact factor: 3.015
Authors: Jon R Sobus; Michael D McClean; Robert F Herrick; Suramya Waidyanatha; Leena A Nylander-French; Lawrence L Kupper; Stephen M Rappaport Journal: Ann Occup Hyg Date: 2009-07-14
Authors: Jon R Sobus; Michael D McClean; Robert F Herrick; Suramya Waidyanatha; Frank Onyemauwa; Lawrence L Kupper; Stephen M Rappaport Journal: Ann Occup Hyg Date: 2009-07-14