OBJECTIVES: To investigate the association of carotenoids and retinol (vitamin A) with intestinal barrier function in children in an urban community in Fortaleza, northeastern Brazil. METHODS: Descriptive analysis of serum carotenoids and retinol concentrations with intestinal barrier function in 102 children from an urban community, July 2000 to August 2001. RESULTS: The weight for height z score (wasting) showed that 19.6% (20/102) had mild malnutrition (-1 to -2 z score). All of the children's serum retinol concentrations were determined and none were severely deficient (< or =0.35 micromol/L), 2.9% (3/102) were moderately (0.36-0.70 micromol/L) deficient, 20.6% (21/102) were mildly (0.71-1.05 micromol/L) deficient; 76.5% (78/102) were vitamin A sufficient (>1.05 micromol/L). The lactulose:mannitol (L/M) ratio was elevated (> or =0.0864) in 49% (47/97) of children when compared with healthy children with normal L/M ratio (<0.0864) in the same geographic area. Serum carotenoids, lutein, beta-cryptoxanthin and beta-carotene showed significant inverse correlations with the L/M ratio, but not lutein after adjusting for age. Acute phase proteins (C-reactive protein and alpha-acid glycoprotein) were significantly inversely correlated with retinol but not with carotenoids. Retinol and retinol-binding protein were not significantly associated with L/M ratio. CONCLUSIONS: These data suggest a disruption of intestinal barrier function in the paracellular pathway with low serum concentrations of carotenoids. Carotenoids may provide a better marker for disrupted intestinal barrier function than retinol-binding protein or retinol.
OBJECTIVES: To investigate the association of carotenoids and retinol (vitamin A) with intestinal barrier function in children in an urban community in Fortaleza, northeastern Brazil. METHODS: Descriptive analysis of serum carotenoids and retinol concentrations with intestinal barrier function in 102 children from an urban community, July 2000 to August 2001. RESULTS: The weight for height z score (wasting) showed that 19.6% (20/102) had mild malnutrition (-1 to -2 z score). All of the children's serum retinol concentrations were determined and none were severely deficient (< or =0.35 micromol/L), 2.9% (3/102) were moderately (0.36-0.70 micromol/L) deficient, 20.6% (21/102) were mildly (0.71-1.05 micromol/L) deficient; 76.5% (78/102) were vitamin A sufficient (>1.05 micromol/L). The lactulose:mannitol (L/M) ratio was elevated (> or =0.0864) in 49% (47/97) of children when compared with healthy children with normal L/M ratio (<0.0864) in the same geographic area. Serum carotenoids, lutein, beta-cryptoxanthin and beta-carotene showed significant inverse correlations with the L/M ratio, but not lutein after adjusting for age. Acute phase proteins (C-reactive protein and alpha-acid glycoprotein) were significantly inversely correlated with retinol but not with carotenoids. Retinol and retinol-binding protein were not significantly associated with L/M ratio. CONCLUSIONS: These data suggest a disruption of intestinal barrier function in the paracellular pathway with low serum concentrations of carotenoids. Carotenoids may provide a better marker for disrupted intestinal barrier function than retinol-binding protein or retinol.
Authors: Deborah A Swartz-Basile; Lihua Wang; Yuzhu Tang; Henry A Pitt; Deborah C Rubin; Marc S Levin Journal: Am J Physiol Gastrointest Liver Physiol Date: 2003-04-23 Impact factor: 4.052
Authors: S M Filteau; N C Rollins; A Coutsoudis; K R Sullivan; J F Willumsen; A M Tomkins Journal: J Pediatr Gastroenterol Nutr Date: 2001-04 Impact factor: 2.839
Authors: L Quadro; M V Gamble; S Vogel; A A Lima; R Piantedosi; S R Moore; V Colantuoni; M E Gottesman; R L Guerrant; W S Blaner Journal: J Infect Dis Date: 2000-09 Impact factor: 5.226
Authors: Kulandaipalayam N C Sindhu; Thuppal V Sowmyanarayanan; Anu Paul; Sudhir Babji; Sitara S R Ajjampur; Sophia Priyadarshini; Rajiv Sarkar; K A Balasubramanian; Christine A Wanke; Honorine D Ward; Gagandeep Kang Journal: Clin Infect Dis Date: 2014-02-05 Impact factor: 9.079
Authors: Aldo A M Lima; Alberto M Soares; Noélia L Lima; Rosa M S Mota; Bruna L L Maciel; Michelle P Kvalsund; Leah J Barrett; Relana P Fitzgerald; William S Blaner; Richard L Guerrant Journal: J Pediatr Gastroenterol Nutr Date: 2010-03 Impact factor: 2.839
Authors: Sumeet S Mitter; Reinaldo B Oriá; Michelle P Kvalsund; Paula Pamplona; Emanuella Silva Joventino; Rosa M S Mota; Davi C Gonçalves; Peter D Patrick; Richard L Guerrant; Aldo A M Lima Journal: Clinics (Sao Paulo) Date: 2012 Impact factor: 2.365
Authors: W A Faubion; M Camilleri; J A Murray; P Kelly; B Amadi; M N Kosek; F Enders; J Larson; G Boe; R Dyer; R Singh Journal: BMJ Glob Health Date: 2016-07-04
Authors: Pedro Henrique Q S de Medeiros; Daniel V Pinto; Juliana Zani de Almeida; Juliana M C Rêgo; Francisco A P Rodrigues; Aldo Ângelo M Lima; David T Bolick; Richard L Guerrant; Reinaldo B Oriá Journal: Nutrients Date: 2018-08-21 Impact factor: 5.717