Literature DB >> 18955530

Optimized elution of daptomycin from polymethylmethacrylate beads.

Brian D Weiss1, Elizabeth C Weiss, Warren O Haggard, Richard P Evans, Sandra G McLaren, Mark S Smeltzer.   

Abstract

We demonstrate that xylitol can be added to polymethylmethacrylate (PMMA) bone cement to enhance the elution of daptomycin in terms of both the peak and sustained release of antibiotic. We also demonstrate that a PMMA-xylitol formulation optimized for daptomycin can be used to enhance the elution of both vancomycin and gentamicin.

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Year:  2008        PMID： 18955530      PMCID： PMC2612151          DOI： 10.1128/AAC.00258-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  8 in total

Review 1.  The current status of material used for depot delivery of drugs.

Authors:  Carl L Nelson
Journal:  Clin Orthop Relat Res       Date:  2004-10       Impact factor: 4.176

Review 2.  Local antibiotic therapy in the treatment of open fractures and osteomyelitis.

Authors:  Charalampos G Zalavras; Michael J Patzakis; Paul Holtom
Journal:  Clin Orthop Relat Res       Date:  2004-10       Impact factor: 4.176

3.  Xylitol and glycine fillers increase permeability of PMMA to enhance elution of daptomycin.

Authors:  Alex C McLaren; Sandra G McLaren; Mark Smeltzer
Journal:  Clin Orthop Relat Res       Date:  2006-10       Impact factor: 4.176

4.  The effect of glycine filler on the elution rate of gentamicin from acrylic bone cement: a pilot study.

Authors:  Alex C McLaren; Carl L Nelson; Sandra G McLaren; G R DeCLerk
Journal:  Clin Orthop Relat Res       Date:  2004-10       Impact factor: 4.176

Review 5.  Osteomyelitis.

Authors:  Daniel P Lew; Francis A Waldvogel
Journal:  Lancet       Date:  2004 Jul 24-30       Impact factor: 79.321

6.  In vitro elution characteristics of commercially and noncommercially prepared antibiotic PMMA beads.

Authors:  C L Nelson; F M Griffin; B H Harrison; R E Cooper
Journal:  Clin Orthop Relat Res       Date:  1992-11       Impact factor: 4.176

7.  Elution behavior of daptomycin-loaded calcium sulfate pellets: a preliminary study.

Authors:  Kelly C Richelsoph; Nathan D Webb; Warren O Haggard
Journal:  Clin Orthop Relat Res       Date:  2007-08       Impact factor: 4.176

8.  Sucrose, xylitol, and erythritol increase PMMA permeability for depot antibiotics.

Authors:  Alex C McLaren; Sandra G McLaren; Miranda K Hickmon
Journal:  Clin Orthop Relat Res       Date:  2007-08       Impact factor: 4.176
  8 in total
  8 in total

1.  Comparative Study of Antibiotic Elution Profiles From Alternative Formulations of Polymethylmethacrylate Bone Cement.

Authors:  Daniel G Meeker; Kasa B Cooper; Regis L Renard; Simon C Mears; Mark S Smeltzer; C Lowry Barnes
Journal:  J Arthroplasty       Date:  2019-03-12       Impact factor: 4.757

2.  Chitosan coating to enhance the therapeutic efficacy of calcium sulfate-based antibiotic therapy in the treatment of chronic osteomyelitis.

Authors:  Karen E Beenken; James K Smith; Robert A Skinner; Sandra G Mclaren; William Bellamy; M Johannes Gruenwald; Horace J Spencer; Jessica A Jennings; Warren O Haggard; Mark S Smeltzer
Journal:  J Biomater Appl       Date:  2014-05-21       Impact factor: 2.646

3.  Novel Antibiotic-loaded Point-of-care Implant Coating Inhibits Biofilm.

Authors:  Jessica Amber Jennings; Daniel P Carpenter; Karen S Troxel; Karen E Beenken; Mark S Smeltzer; Harry S Courtney; Warren O Haggard
Journal:  Clin Orthop Relat Res       Date:  2015-07       Impact factor: 4.176

4.  Local release of antibiotics for surgical site infection management using high-purity calcium sulfate: an in vitro elution study.

Authors:  Sean S Aiken; John J Cooper; Hannah Florance; Matthew T Robinson; Stephen Michell
Journal:  Surg Infect (Larchmt)       Date:  2014-08-22       Impact factor: 2.150

5.  Use of xylitol to enhance the therapeutic efficacy of polymethylmethacrylate-based antibiotic therapy in treatment of chronic osteomyelitis.

Authors:  Karen E Beenken; Laura Bradney; William Bellamy; Robert A Skinner; Sandra G McLaren; M Johannes Gruenwald; Horace J Spencer; James K Smith; Warren O Haggard; Mark S Smeltzer
Journal:  Antimicrob Agents Chemother       Date:  2012-09-04       Impact factor: 5.191

Review 6.  Management of acute hematogenous osteomyelitis in children.

Authors:  Nada S Harik; Mark S Smeltzer
Journal:  Expert Rev Anti Infect Ther       Date:  2010-02       Impact factor: 5.091

Review 7.  Role of Implantable Drug Delivery Devices with Dual Platform Capabilities in the Prevention and Treatment of Bacterial Osteomyelitis.

Authors:  Caroline Billings; David E Anderson
Journal:  Bioengineering (Basel)       Date:  2022-02-06

8.  Does the Addition of Poly(glycolide-co-lactide) to Teicoplanin-Containing Poly(methyl methacrylate) Beads Change the Elution Characteristics?

Authors:  Seyran Kilinç; Özhan Pazarci; Neşe Keklikcioğlu Çakmak; Ayça Taş
Journal:  Indian J Orthop       Date:  2020-04-24       Impact factor: 1.251
  8 in total

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