Literature DB >> 22948866

Use of xylitol to enhance the therapeutic efficacy of polymethylmethacrylate-based antibiotic therapy in treatment of chronic osteomyelitis.

Karen E Beenken1, Laura Bradney, William Bellamy, Robert A Skinner, Sandra G McLaren, M Johannes Gruenwald, Horace J Spencer, James K Smith, Warren O Haggard, Mark S Smeltzer.   

Abstract

Using a rabbit model of postsurgical osteomyelitis, we demonstrate that incorporation of xylitol into polymethylmethacrylate (PMMA) bone cement enhances the elution of daptomycin under in vivo conditions. We also demonstrate that this can be correlated with an improved therapeutic outcome in the treatment of a chronic bone infection following surgical debridement.

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Year:  2012        PMID： 22948866      PMCID： PMC3486578          DOI： 10.1128/AAC.01127-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

Review 1.  Combination antibiotic therapy for empiric and definitive treatment of gram-negative infections: insights from the Society of Infectious Diseases Pharmacists.

Authors:  Natalie Boyd; Michael D Nailor
Journal:  Pharmacotherapy       Date:  2011-11       Impact factor: 4.705

Review 2.  Biodegradable antibiotic delivery systems.

Authors:  M El-Husseiny; S Patel; R J MacFarlane; F S Haddad
Journal:  J Bone Joint Surg Br       Date:  2011-02

3.  A novel method to control the balance of skin microflora. Part 1. Attack on biofilm of Staphylococcus aureus without antibiotics.

Authors:  Masako Katsuyama; Katsuyama Masako; Hideyuki Ichikawa; Ichikawa Hideyuki; Shigeyuki Ogawa; Ogawa Shigeyuki; Zenro Ikezawa; Ikezawa Zenro
Journal:  J Dermatol Sci       Date:  2005-03-02       Impact factor: 4.563

4.  Xylitol and glycine fillers increase permeability of PMMA to enhance elution of daptomycin.

Authors:  Alex C McLaren; Sandra G McLaren; Mark Smeltzer
Journal:  Clin Orthop Relat Res       Date:  2006-10       Impact factor: 4.176

5.  Characterization of a rabbit model of staphylococcal osteomyelitis.

Authors:  M S Smeltzer; J R Thomas; S G Hickmon; R A Skinner; C L Nelson; D Griffith; T R Parr; R P Evans
Journal:  J Orthop Res       Date:  1997-05       Impact factor: 3.494

6.  The effect of glycine filler on the elution rate of gentamicin from acrylic bone cement: a pilot study.

Authors:  Alex C McLaren; Carl L Nelson; Sandra G McLaren; G R DeCLerk
Journal:  Clin Orthop Relat Res       Date:  2004-10       Impact factor: 4.176

7.  Particle size of fillers affects permeability of polymethylmethacrylate.

Authors:  A C McLaren; S G McLaren; R McLemore; B L Vernon
Journal:  Clin Orthop Relat Res       Date:  2007-08       Impact factor: 4.176

8.  Role of the accessory gene regulator (agr) in pathogenesis of staphylococcal osteomyelitis.

Authors:  A F Gillaspy; S G Hickmon; R A Skinner; J R Thomas; C L Nelson; M S Smeltzer
Journal:  Infect Immun       Date:  1995-09       Impact factor: 3.441

Review 9.  Osteomyelitis.

Authors:  Daniel P Lew; Francis A Waldvogel
Journal:  Lancet       Date:  2004 Jul 24-30       Impact factor: 79.321

10.  Sucrose, xylitol, and erythritol increase PMMA permeability for depot antibiotics.

Authors:  Alex C McLaren; Sandra G McLaren; Miranda K Hickmon
Journal:  Clin Orthop Relat Res       Date:  2007-08       Impact factor: 4.176
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  6 in total

1.  Chitosan coating to enhance the therapeutic efficacy of calcium sulfate-based antibiotic therapy in the treatment of chronic osteomyelitis.

Authors:  Karen E Beenken; James K Smith; Robert A Skinner; Sandra G Mclaren; William Bellamy; M Johannes Gruenwald; Horace J Spencer; Jessica A Jennings; Warren O Haggard; Mark S Smeltzer
Journal:  J Biomater Appl       Date:  2014-05-21       Impact factor: 2.646

2.  Chitosan sponges for local synergistic infection therapy: a pilot study.

Authors:  J Keaton Smith; Abteen R Moshref; Jessica A Jennings; Harry S Courtney; Warren O Haggard
Journal:  Clin Orthop Relat Res       Date:  2013-04-20       Impact factor: 4.176

3.  Evaluation of Antibiotics Active against Methicillin-Resistant Staphylococcus aureus Based on Activity in an Established Biofilm.

Authors:  Daniel G Meeker; Karen E Beenken; Weston B Mills; Allister J Loughran; Horace J Spencer; William B Lynn; Mark S Smeltzer
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

4.  Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone.

Authors:  Zaineb A F Albayati; Manjula Sunkara; Suzannah M Schmidt-Malan; Melissa J Karau; Andrew J Morris; James M Steckelberg; Robin Patel; Philip J Breen; Mark S Smeltzer; K Grant Taylor; Kevyn E Merten; William M Pierce; Peter A Crooks
Journal:  Antimicrob Agents Chemother       Date:  2015-12-14       Impact factor: 5.191

5.  Polylactic-co-glycolic acid microspheres added to fixative cements and its role on bone infected architecture.

Authors:  Blanca Ibarra; Joaquin García-García; Galo Azuara; Blanca Vázquez-Lasa; Miguel A Ortega; Ángel Asúnsolo; Julio San Román; Julia Buján; Natalio García-Honduvilla; Basilio De la Torre
Journal:  J Biomed Mater Res B Appl Biomater       Date:  2019-02-19       Impact factor: 3.368

6.  In vivo evaluation of temperature-responsive antimicrobial-loaded PNIPAAm hydrogels for prevention of surgical site infection.

Authors:  John M Heffernan; Derek J Overstreet; Brent L Vernon; Ryan Y McLemore; Tamas Nagy; Rex C Moore; Vajra S Badha; Erin P Childers; Michael B Nguyen; Daniel D Gentry; Francis M Calara; W Brian Saunders; Tim Feltis; Alex C McLaren
Journal:  J Biomed Mater Res B Appl Biomater       Date:  2021-06-15       Impact factor: 3.368
  6 in total

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