Literature DB >> 18953715

Novel strategies to identify biomarkers in tuberculosis.

Marc Jacobsen1, Jens Mattow, Dirk Repsilber, Stefan H E Kaufmann.   

Abstract

The more we learn about the immune response against tuberculosis (TB) and particularly about the features which distinguish protective immunity, disease susceptibility and pathology, the better we can define biomarkers which correlate with these different stages of infection. The most widely used biomarker in TB, which without a doubt is an important component of protective immunity, is IFNgamma secreted by antigen-specific CD4 T-cells. However, the complexity of the immune response against TB makes it more than likely that additional biomarkers are required for a reliable correlate of protection. As a corollary, we assume that a set of biomarkers will be required, termed a biosignature.

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Year:  2008        PMID： 18953715     DOI： 10.1515/bc.2008.053

Source DB:  PubMed          Journal:  Biol Chem        ISSN： 1431-6730            Impact factor:   3.915


  17 in total

1.  Anti-phospholipid antibody levels as biomarker for monitoring tuberculosis treatment response.

Authors:  Amador Goodridge; Carla Cueva; Maureen Lahiff; Grace Muzanye; John L Johnson; Payam Nahid; Lee W Riley
Journal:  Tuberculosis (Edinb)       Date:  2012-03-10       Impact factor: 3.131

2.  Total IgM and Anti-Phosphatidylcholine IgM Antibody Secretion Continue After Clearance of Mycobacterium bovis Bacillus Calmette-Guerin Pleural Infection.

Authors:  Ciara Ordoñez; Musharaf Tarajia; René Rivera; Dilcia Sambrano; Victoria Batista; Mónica Chávez; Denis Tapia; Patricia L Fernández; Amador Goodridge
Journal:  Lung       Date:  2017-05-27       Impact factor: 2.584

3.  Diagnostic value of blood gene expression signatures in active tuberculosis in Thais: a pilot study.

Authors:  N Satproedprai; N Wichukchinda; S Suphankong; W Inunchot; T Kuntima; S Kumpeerasart; S Wattanapokayakit; S Nedsuwan; H Yanai; K Higuchi; N Harada; S Mahasirimongkol
Journal:  Genes Immun       Date:  2015-03-12       Impact factor: 2.676

4.  Serological biomarkers for monitoring response to treatment of pulmonary and extrapulmonary tuberculosis in children and adolescents.

Authors:  Danielle C M Dos Santos; Kathryn L Lovero; Christiane M Schmidt; Ana Cláudia M W Barros; Ana Paula Quintanilha; Ana Paula Barbosa; Marcos V S Pone; Sheila M Pone; Julienne Martins Araujo; Camila de Paula Martins; Estela Magalhães Cosme; Thais Raquelly Dourado de Oliveira; Ana Lúcia Miceli; Maria Luíza Vieira; Adriano Queiroz; Luis Guillermo Coca Velarde; Afranio Kritski; Maria de Fátima Pombo March; Selma Maria de Azevedo Sias; Clemax C SantÀAnna; Lee W Riley; Claudete A Araújo Cardoso
Journal:  Tuberculosis (Edinb)       Date:  2020-06-26       Impact factor: 3.131

5.  Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children.

Authors:  Adam D Irwin; Fiona Marriage; Limangeni A Mankhambo; Graham Jeffers; Ruwanthi Kolamunnage-Dona; Malcolm Guiver; Brigitte Denis; Elizabeth M Molyneux; Malcolm E Molyneux; Philip J Day; Enitan D Carrol
Journal:  BMC Med Genomics       Date:  2012-05-04       Impact factor: 3.063

6.  Gram-negative and Gram-positive bacterial infections give rise to a different metabolic response in a mouse model.

Authors:  Verena Hoerr; Lori Zbytnuik; Caroline Leger; Patrick P C Tam; Paul Kubes; Hans J Vogel
Journal:  J Proteome Res       Date:  2012-05-03       Impact factor: 4.466

7.  Identification of T-cell antigens specific for latent mycobacterium tuberculosis infection.

Authors:  Sebastian D Schuck; Henrik Mueller; Frank Kunitz; Albert Neher; Harald Hoffmann; Kees L C M Franken; Dirk Repsilber; Tom H M Ottenhoff; Stefan H E Kaufmann; Marc Jacobsen
Journal:  PLoS One       Date:  2009-05-18       Impact factor: 3.240

8.  Identification of major factors influencing ELISpot-based monitoring of cellular responses to antigens from Mycobacterium tuberculosis.

Authors:  Steven G Smith; Simone A Joosten; Virginie Verscheure; Ansar A Pathan; Helen McShane; Tom H M Ottenhoff; Hazel M Dockrell; Françoise Mascart
Journal:  PLoS One       Date:  2009-11-24       Impact factor: 3.240

9.  Biomarker discovery in heterogeneous tissue samples -taking the in-silico deconfounding approach.

Authors:  Dirk Repsilber; Sabine Kern; Anna Telaar; Gerhard Walzl; Gillian F Black; Joachim Selbig; Shreemanta K Parida; Stefan H E Kaufmann; Marc Jacobsen
Journal:  BMC Bioinformatics       Date:  2010-01-14       Impact factor: 3.169

10.  Are microRNAs suitable biomarkers of immunity to tuberculosis?

Authors:  Bianca Ueberberg; Malte Kohns; Ertan Mayatepek; Marc Jacobsen
Journal:  Mol Cell Pediatr       Date:  2014-10-03
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