OBJECTIVES: Exposures during early life may affect risk of breast cancer. History of tonsillectomy has recently been associated with risk of several cancers, including cancer of the breast. METHODS: We conducted a population-based case-control study of women living in Western New York from 1986 to 1991. Cases had incident, primary, pathologically confirmed breast cancer and were recruited through all major hospitals in the region (n = 740). Population-based controls (n = 810) were randomly sampled from among drivers' license holders from Department of Motor Vehicles records (<65 yrs) and from Health Care Finance Administration records (> or =65 yrs). Participants were interviewed with regard to diet, anthropometrics, demographics, medical, and reproductive history. Unconditional logistic regression models stratified by menopausal status were used to estimate multivariate odds ratios (OR) and 95% confidence intervals (95% CI). RESULTS: A history of tonsillectomy was associated with increased breast cancer risk among premenopausal (OR 1.50, 95% CI: 1.08-2.08) but not postmenopausal women (OR 1.05, 95% CI: 0.79-1.38). CONCLUSIONS: Our findings add to accumulating data implicating tonsillectomy in risk of cancer. Tonsillectomy may be an indicator for conditions of chronic inflammation and/or reduced efficiency of immune function. Our study also provides additional evidence that early life exposures may affect premenopausal breast cancer risk.
OBJECTIVES: Exposures during early life may affect risk of breast cancer. History of tonsillectomy has recently been associated with risk of several cancers, including cancer of the breast. METHODS: We conducted a population-based case-control study of women living in Western New York from 1986 to 1991. Cases had incident, primary, pathologically confirmed breast cancer and were recruited through all major hospitals in the region (n = 740). Population-based controls (n = 810) were randomly sampled from among drivers' license holders from Department of Motor Vehicles records (<65 yrs) and from Health Care Finance Administration records (> or =65 yrs). Participants were interviewed with regard to diet, anthropometrics, demographics, medical, and reproductive history. Unconditional logistic regression models stratified by menopausal status were used to estimate multivariate odds ratios (OR) and 95% confidence intervals (95% CI). RESULTS: A history of tonsillectomy was associated with increased breast cancer risk among premenopausal (OR 1.50, 95% CI: 1.08-2.08) but not postmenopausal women (OR 1.05, 95% CI: 0.79-1.38). CONCLUSIONS: Our findings add to accumulating data implicating tonsillectomy in risk of cancer. Tonsillectomy may be an indicator for conditions of chronic inflammation and/or reduced efficiency of immune function. Our study also provides additional evidence that early life exposures may affect premenopausal breast cancer risk.
Authors: Susan E McCann; Lilian U Thompson; Jing Nie; Joan Dorn; Maurizio Trevisan; Peter G Shields; Christine B Ambrosone; Stephen B Edge; Hsin-Fang Li; Christina Kasprzak; Jo L Freudenheim Journal: Breast Cancer Res Treat Date: 2009-12-22 Impact factor: 4.872
Authors: Scott Sauer; Dylan Beinart; Sade M B Finn; Sereena L Kumar; Qing Cheng; Shelley E Hwang; William Parker; Gayathri R Devi Journal: Evol Med Public Health Date: 2021-02-12
Authors: Salah Eddine O Kacimi; Anas Elgenidy; Huzaifa Ahmad Cheema; Mounir Ould Setti; Atulya Aman Khosla; Amira Yasmine Benmelouka; Mohammad Aloulou; Kawthar Djebabria; Laila Salah Shamseldin; Omar Riffi; Nabil Smain Mesli; Hanane Z Sekkal; Ahmed M Afifi; Jaffer Shah; Sherief Ghozy Journal: Front Oncol Date: 2022-07-20 Impact factor: 5.738