OBJECTIVE: To examine the relationship of depression to metabolic and nutritional risk factors in older Hispanics. DESIGN: Crossectional study. SETTING: Subjects were part of a community-based, cognitive evaluation project that examined 301 subjects in the Eastern San Fernando Valley of Southern California. PARTICIPANTS: Two elderly Hispanic groups: 53 clinically depressed, with memory complaints but not demented subjects, and 33 generally healthy, cognitively asymptomatic subjects. MEASUREMENTS: The results of functional and nutritional questionnaires, a medical and neurological examination, 12-hour fasting clinical laboratory tests, MRI or CT scans, and neuropsychological testing. RESULTS: Both groups were nearly identical along socio-demographic variables. However, the depressed group differed significantly from the general healthy group not only in percent of diabetics (38% vs.18%), but in the amount of poorly controlled diabetes, and the depressed group consumed about half the amount of fish that the generally healthy group did. CONCLUSIONS: This study suggests that factors such as poorly controlled diabetes combined with low consumption of foods high in omega-3 fatty acid content such as sea fish may be associated with an increased risk of developing depression in late life. These factors may be socio-economically and culturally influenced and are therefore amenable to modification.
OBJECTIVE: To examine the relationship of depression to metabolic and nutritional risk factors in older Hispanics. DESIGN: Crossectional study. SETTING: Subjects were part of a community-based, cognitive evaluation project that examined 301 subjects in the Eastern San Fernando Valley of Southern California. PARTICIPANTS: Two elderly Hispanic groups: 53 clinically depressed, with memory complaints but not demented subjects, and 33 generally healthy, cognitively asymptomatic subjects. MEASUREMENTS: The results of functional and nutritional questionnaires, a medical and neurological examination, 12-hour fasting clinical laboratory tests, MRI or CT scans, and neuropsychological testing. RESULTS: Both groups were nearly identical along socio-demographic variables. However, the depressed group differed significantly from the general healthy group not only in percent of diabetics (38% vs.18%), but in the amount of poorly controlled diabetes, and the depressed group consumed about half the amount of fish that the generally healthy group did. CONCLUSIONS: This study suggests that factors such as poorly controlled diabetes combined with low consumption of foods high in omega-3 fatty acid content such as sea fish may be associated with an increased risk of developing depression in late life. These factors may be socio-economically and culturally influenced and are therefore amenable to modification.
Authors: Christopher M Clark; Charles DeCarli; Dan Mungas; Helena I Chui; Roger Higdon; Jessica Nuñez; Henrique Fernandez; Mirna Negrón; Jennifer Manly; Steven Ferris; Angelica Perez; Migdalia Torres; Douglas Ewbank; Guila Glosser; Gerald van Belle Journal: Arch Neurol Date: 2005-05
Authors: Melek C Arkan; Andrea L Hevener; Florian R Greten; Shin Maeda; Zhi-Wei Li; Jeffrey M Long; Anthony Wynshaw-Boris; Giuseppe Poli; Jerrold Olefsky; Michael Karin Journal: Nat Med Date: 2005-01-30 Impact factor: 53.440
Authors: Angelica P Herrera; Matthew Lee Smith; Marcia G Ory; Hector P Rodriguez; Ruth Warre; Wesley K Thompson; Annette Azcue; Jairo A Romero Journal: J Aging Health Date: 2011-10
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