Literature DB >> 18952571

Cyclooxygenases: structural and functional insights.

Carol A Rouzer1, Lawrence J Marnett.   

Abstract

Cyclooxygenase (COX; prostaglandin G/H synthase, EC 1.14.99.1) catalyzes the first two steps in the biosynthesis of prostaglandins (PGs). The two COX isoforms COX-1 and COX-2 are the targets of the widely used nonsteroidal anti-inflammatory drugs, indicating a role for these enzymes in pain, fever, inflammation, and tumorigenesis. The ubiquitous constitutive expression of COX-1 and inducible expression of COX-2 have led to the widely held belief that COX-1 produces homeostatic PGs, while PGs produced by COX-2 are primarily pathophysiological. However, recent discoveries call this paradigm into question and reveal as yet underappreciated functions for both enzymes. This review focuses on some of these new insights.

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Year:  2008        PMID： 18952571      PMCID： PMC2674713          DOI： 10.1194/jlr.R800042-JLR200

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  45 in total

Review 1.  Why there are two cyclooxygenase isozymes.

Authors:  W L Smith; R Langenbach
Journal:  J Clin Invest       Date:  2001-06       Impact factor: 14.808

Review 2.  Cyclooxygenases: structural, cellular, and molecular biology.

Authors:  W L Smith; D L DeWitt; R M Garavito
Journal:  Annu Rev Biochem       Date:  2000       Impact factor: 23.643

3.  Metabolism of prostaglandin glycerol esters and prostaglandin ethanolamides in vitro and in vivo.

Authors:  K R Kozak; B C Crews; J L Ray; H H Tai; J D Morrow; L J Marnett
Journal:  J Biol Chem       Date:  2001-07-10       Impact factor: 5.157

Review 4.  The structures of prostaglandin endoperoxide H synthases-1 and -2.

Authors:  R Michael Garavito; Michael G Malkowski; David L DeWitt
Journal:  Prostaglandins Other Lipid Mediat       Date:  2002-08       Impact factor: 3.072

Review 5.  Distinct functions of COX-1 and COX-2.

Authors:  Ikuo Morita
Journal:  Prostaglandins Other Lipid Mediat       Date:  2002-08       Impact factor: 3.072

6.  Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.

Authors:  A S Kalgutkar; A B Marnett; B C Crews; R P Remmel; L J Marnett
Journal:  J Med Chem       Date:  2000-07-27       Impact factor: 7.446

7.  NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2.

Authors:  J L Wallace; W McKnight; B K Reuter; N Vergnolle
Journal:  Gastroenterology       Date:  2000-09       Impact factor: 22.682

8.  Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation.

Authors:  B F McAdam; I A Mardini; A Habib; A Burke; J A Lawson; S Kapoor; G A FitzGerald
Journal:  J Clin Invest       Date:  2000-05       Impact factor: 14.808

9.  Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete.

Authors:  S W Rowlinson; B C Crews; D C Goodwin; C Schneider; J K Gierse; L J Marnett
Journal:  J Biol Chem       Date:  2000-03-03       Impact factor: 5.157

10.  Cyclooxygenase in normal human tissues--is COX-1 really a constitutive isoform, and COX-2 an inducible isoform?

Authors:  Nina Zidar; Katarina Odar; Damjan Glavac; Maja Jerse; Tomaz Zupanc; Dusan Stajer
Journal:  J Cell Mol Med       Date:  2008-07-24       Impact factor: 5.310
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  172 in total

1.  Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice.

Authors:  Molly S Crowe; Emma Leishman; Matthew L Banks; Ramesh Gujjar; Anu Mahadevan; Heather B Bradshaw; Steven G Kinsey
Journal:  Br J Pharmacol       Date:  2015-01-20       Impact factor: 8.739

Review 2.  Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis.

Authors:  William L Smith; Yoshihiro Urade; Per-Johan Jakobsson
Journal:  Chem Rev       Date:  2011-09-27       Impact factor: 60.622

3.  Bidirectional crosstalk via IL-6, PGE2 and PGD2 between murine myofibroblasts and alternatively activated macrophages enhances anti-inflammatory phenotype in both cells.

Authors:  Maria R Fernando; Mark A Giembycz; Derek M McKay
Journal:  Br J Pharmacol       Date:  2016-02-08       Impact factor: 8.739

Review 4.  Cyclooxygenase-2 and cancer treatment: understanding the risk should be worth the reward.

Authors:  David G Menter; Richard L Schilsky; Raymond N DuBois
Journal:  Clin Cancer Res       Date:  2010-02-23       Impact factor: 12.531

Review 5.  Adjunctive use of nonsteroidal anti-inflammatory drugs for schizophrenia: a meta-analytic investigation of randomized controlled trials.

Authors:  Masahiro Nitta; Taishiro Kishimoto; Norbert Müller; Mark Weiser; Michael Davidson; John M Kane; Christoph U Correll
Journal:  Schizophr Bull       Date:  2013-05-29       Impact factor: 9.306

6.  Silymarin and celecoxib ameliorate experimental varicocele-induced pathogenesis: evidences for oxidative stress and inflammation inhibition.

Authors:  Sara Mazhari; Mazdak Razi; Rajabali Sadrkhanlou
Journal:  Int Urol Nephrol       Date:  2018-04-05       Impact factor: 2.370

Review 7.  Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications.

Authors:  Daniela Salvemini; Sangwon F Kim; Vincenzo Mollace
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2013-02-06       Impact factor: 3.619

8.  Transcription factor Ets-1 inhibits glucose-stimulated insulin secretion of pancreatic β-cells partly through up-regulation of COX-2 gene expression.

Authors:  Xiong-Fei Zhang; Yi Zhu; Wen-Biao Liang; Jing-Jing Zhang
Journal:  Endocrine       Date:  2013-11-28       Impact factor: 3.633

9.  Adiposity Results in Metabolic and Inflammation Differences in Premenopausal and Postmenopausal Women Consistent with the Difference in Breast Cancer Risk.

Authors:  H Zhao; J Wang; D Fang; O Lee; R T Chatterton; V Stearns; S A Khan; S E Bulun
Journal:  Horm Cancer       Date:  2018-03-15       Impact factor: 3.869

10.  Cell-type-specific roles for COX-2 in UVB-induced skin cancer.

Authors:  Jing Jiao; Carol Mikulec; Tomo-o Ishikawa; Clara Magyar; Darren S Dumlao; Edward A Dennis; Susan M Fischer; Harvey Herschman
Journal:  Carcinogenesis       Date:  2014-01-27       Impact factor: 4.944
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