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Literature DB >> 11413152

Why there are two cyclooxygenase isozymes.

W L Smith¹, R Langenbach.

Abstract

Mesh：

Substances：

Year: 2001 PMID： 11413152 PMCID： PMC200199 DOI： 10.1172/JCI13271

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

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38 in total

1. Differential allosteric regulation of prostaglandin H synthase 1 and 2 by arachidonic acid.

Authors: D C Swinney; A Y Mak; J Barnett; C S Ramesha
Journal: J Biol Chem Date: 1997-05-09 Impact factor: 5.157

2. Multiple female reproductive failures in cyclooxygenase 2-deficient mice.

Authors: H Lim; B C Paria; S K Das; J E Dinchuk; R Langenbach; J M Trzaskos; S K Dey
Journal: Cell Date: 1997-10-17 Impact factor: 41.582

3. Distinct roles of prostaglandin H synthases 1 and 2 in T-cell development.

Authors: B Rocca; L M Spain; E Puré; R Langenbach; C Patrono; G A FitzGerald
Journal: J Clin Invest Date: 1999-05-15 Impact factor: 14.808

4. Role of cyclooxygenase-2 in the healing of gastric ulcers in rats.

Authors: J Shigeta; S Takahashi; S Okabe
Journal: J Pharmacol Exp Ther Date: 1998-09 Impact factor: 4.030

5. Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1beta.

Authors: B J Davis; D E Lennard; C A Lee; H F Tiano; S G Morham; W C Wetsel; R Langenbach
Journal: Endocrinology Date: 1999-06 Impact factor: 4.736

6. Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy.

Authors: A G Spencer; J W Woods; T Arakawa; I I Singer; W L Smith
Journal: J Biol Chem Date: 1998-04-17 Impact factor: 5.157

Review 7. Prevention of myocardial infarction and stroke by aspirin: different mechanisms? Different dosage?

Authors: C Patrono
Journal: Thromb Res Date: 1998-09-15 Impact factor: 3.944

8. Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: implications for gastrointestinal toxicity.

Authors: J L Wallace; A Bak; W McKnight; S Asfaha; K A Sharkey; W K MacNaughton
Journal: Gastroenterology Date: 1998-07 Impact factor: 22.682

9. Opposing actions of prostaglandins and oxytocin determine the onset of murine labor.

Authors: G A Gross; T Imamura; C Luedke; S K Vogt; L M Olson; D M Nelson; Y Sadovsky; L J Muglia
Journal: Proc Natl Acad Sci U S A Date: 1998-09-29 Impact factor: 11.205

10. Functional coupling between various phospholipase A2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways.

Authors: M Murakami; T Kambe; S Shimbara; I Kudo
Journal: J Biol Chem Date: 1999-01-29 Impact factor: 5.157

105 in total

Review 1. Genetic and pharmacological analysis of prostanoid receptor function.

Authors: S Narumiya; G A FitzGerald
Journal: J Clin Invest Date: 2001-07 Impact factor: 14.808

Review 2. Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways.

Authors: C N Serhan; E Oliw
Journal: J Clin Invest Date: 2001-06 Impact factor: 14.808

Review 3. Regulated formation of eicosanoids.

Authors: F A Fitzpatrick; R Soberman
Journal: J Clin Invest Date: 2001-06 Impact factor: 14.808

Why there are two cyclooxygenase isozymes.

1. Differential allosteric regulation of prostaglandin H synthase 1 and 2 by arachidonic acid.

2. Multiple female reproductive failures in cyclooxygenase 2-deficient mice.

3. Distinct roles of prostaglandin H synthases 1 and 2 in T-cell development.

4. Role of cyclooxygenase-2 in the healing of gastric ulcers in rats.

5. Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1beta.

6. Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy.

Review 7. Prevention of myocardial infarction and stroke by aspirin: different mechanisms? Different dosage?

8. Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: implications for gastrointestinal toxicity.

9. Opposing actions of prostaglandins and oxytocin determine the onset of murine labor.

10. Functional coupling between various phospholipase A2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways.

Review 1. Genetic and pharmacological analysis of prostanoid receptor function.

Review 2. Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways.

Review 3. Regulated formation of eicosanoids.

4. The expanding network of redox signaling: new observations, complexities, and perspectives.

Review 5. What is the role of NSAIDs in pre-emptive analgesia?

Review 6. The choreography of cyclooxygenases in the kidney.

Review 7. The organization and consequences of eicosanoid signaling.

Review 8. Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis.

9. Detergents profoundly affect inhibitor potencies against both cyclo-oxygenase isoforms.

Review 10. Cyclooxygenases: structural and functional insights.