Literature DB >> 18952424

Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246.

Yoshihito Shiono1, Keiko Shimanuki, Fuminori Hiramatsu, Takuya Koseki, Murayama Tetsuya, Nozomi Fujisawa, Ken-ichi Kimura.   

Abstract

Pyrrospirones A and B have been isolated from unpolished rice cultures of the endophytic fungus Neonectria ramulariae Wollenw KS-246. Their absolute stereostructures (1 and 2) were elucidated through spectroscopic methods using 1D and 2D NMR techniques and chemical transformations, including the modified Mosher's method. The compounds exhibited cytotoxicity and induced apoptosis in human promyelocytic leukemia HL-60 cells.

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Year:  2008        PMID： 18952424     DOI： 10.1016/j.bmcl.2008.10.032

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

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Authors:  E M Kithsiri Wijeratne; Hongping He; Scott G Franzblau; Angela M Hoffman; A A Leslie Gunatilaka
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3.  Xenoacremones D-H, Bioactive Tyrosine-decahydrofluorene Analogues from the Plant-Derived Fungus Xenoacremonium sinensis.

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Journal:  Mar Drugs       Date:  2022-05-31       Impact factor: 6.085

4.  Total synthesis of hirsutellone B.

Authors:  K C Nicolaou; David Sarlah; T Robert Wu; Weiqiang Zhan
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

5.  Toward a synthesis of hirsutellone B by the concept of double cyclization.

Authors:  Keith P Reber; S David Tilley; Cheryl A Carson; Erik J Sorensen
Journal:  J Org Chem       Date:  2013-09-23       Impact factor: 4.354

6.  Pyrrocidine A, a metabolite of endophytic fungi, has a potent apoptosis-inducing activity against HL60 cells through caspase activation via the Michael addition.

Authors:  Shota Uesugi; Nozomi Fujisawa; Jun Yoshida; Mitsuru Watanabe; Shingo Dan; Takao Yamori; Yoshihito Shiono; Ken-ichi Kimura
Journal:  J Antibiot (Tokyo)       Date:  2015-10-28       Impact factor: 2.649

7.  Bioactive PKS-NRPS Alkaloids from the Plant-Derived Endophytic Fungus Xylaria arbuscula.

Authors:  Ya Wang; Sinan Zhao; Tao Guo; Li Li; Tantan Li; Anqi Wang; Dandan Zhang; Yanlei Wang; Yi Sun
Journal:  Molecules       Date:  2021-12-27       Impact factor: 4.411

8.  A Marine Alkaloid, Ascomylactam A, Suppresses Lung Tumorigenesis via Inducing Cell Cycle G1/S Arrest through ROS/Akt/Rb Pathway.

Authors:  Lan Wang; Yun Huang; Cui-Hong Huang; Jian-Chen Yu; Ying-Chun Zheng; Yan Chen; Zhi-Gang She; Jie Yuan
Journal:  Mar Drugs       Date:  2020-09-27       Impact factor: 5.118
  8 in total

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