| Literature DB >> 18951791 |
Ashok Kumar1, Kumkum Srivastava, S Raja Kumar, S K Puri, Prem M S Chauhan.
Abstract
The emergence and rapid spread of chloroquine resistant strains of Plasmodium falciparum has dramatically reduced the chemotherapeutic options. Towards this goal, a series of new class of hybrid 4-aminoquinoline triazines were synthesized and screened against CQ sensitive strain 3D7 of P. falciparum in an in vitro model. Compounds 65 and 69 exhibited more than 99% suppression on day 4 and on day 6 post treatment, compound 69 showed impressive 99.11% suppression against CQ resistant strain N-67 of P. yoelii in an in vivo assay.Entities:
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Year: 2008 PMID： 18951791 DOI： 10.1016/j.bmcl.2008.10.049
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823