| Literature DB >> 18950628 |
C-M Vacher1, D Crépin, A Aubourg, O Couvreur, V Bailleux, V Nicolas, J Férézou, D Gripois, A Gertler, M Taouis.
Abstract
Administration of CNTF durably reduces food intake and body weight in obese humans and rodent models. However, the involvement of endogenous CNTF in the central regulation of energy homeostasis needs to be elucidated. Here, we demonstrate that CNTF and its receptor are expressed in the arcuate nucleus, a key hypothalamic region controlling food intake, and that CNTF levels are inversely correlated to body weight in rats fed a high-sucrose diet. Thus endogenous CNTF may act, in some individuals, as a protective factor against weight gain during hypercaloric diet and could account for individual differences in the susceptibility to obesity.Entities:
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Year: 2008 PMID： 18950628 DOI： 10.1016/j.febslet.2008.10.018
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124