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Literature DB >> 25178649

Role of BMP7 in appetite regulation, adipogenesis, and energy expenditure.

Supriya Saini¹, Arul Joseph Duraisamy, Susovon Bayen, Praveen Vats, Shashi Bala Singh.

Abstract

Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist, of which BMP7 is of particular interest in this review being a leptin-independent anorexinogen and having role in energy expenditure in the brown adipose tissue, which makes it a potential target for preventing/treating obesity. As it has been established that Obesity displays a state of leptin-resistance, thus a protein-like BMP7 which acts through a leptin-independent pathway could give new therapeutic directions. This review will also discuss the synthesis and action of BMP7, along with its receptors and signal transduction. A brief note about BMP7-mediated brown fat development and energy balance is also discussed.

Entities: Disease Gene

Mesh：

Substances：

Year: 2014 PMID： 25178649 DOI： 10.1007/s12020-014-0406-8

Source DB: PubMed Journal: Endocrine ISSN： 1355-008X Impact factor: 3.633

72 in total

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Journal: Endocrinology Date: 2010-08-04 Impact factor: 4.736

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Authors: Aaron M Cypess; C Ronald Kahn
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8. Brown adipose tissue: Recent insights into development, metabolic function and therapeutic potential.

Authors: Kristy Townsend; Yu-Hua Tseng
Journal: Adipocyte Date: 2012-01-01 Impact factor: 4.534

9. BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality.

Authors: Mariëtte R Boon; Sjoerd A A van den Berg; Yanan Wang; Jan van den Bossche; Sofia Karkampouna; Matthias Bauwens; Marijke De Saint-Hubert; Geertje van der Horst; Slobodan Vukicevic; Menno P J de Winther; Louis M Havekes; J Wouter Jukema; Jouke T Tamsma; Gabri van der Pluijm; Ko Willems van Dijk; Patrick C N Rensen
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Authors: Matthias Blüher
Journal: Mol Metab Date: 2014-01-21 Impact factor: 7.422

8 in total

1. Silk Hydrogel-Mediated Delivery of Bone Morphogenetic Protein 7 Directly to Subcutaneous White Adipose Tissue Increases Browning and Energy Expenditure.

Authors: Kristy L Townsend; Eleanor Pritchard; Jeannine M Coburn; Young Mi Kwon; Magdalena Blaszkiewicz; Matthew D Lynes; David L Kaplan; Yu-Hua Tseng
Journal: Front Bioeng Biotechnol Date: 2022-05-12

2. CRISPR-mediated BMP9 ablation promotes liver steatosis via the down-regulation of PPARα expression.

Authors: Z Yang; P Li; Q Shang; Y Wang; J He; S Ge; R Jia; X Fan
Journal: Sci Adv Date: 2020-11-27 Impact factor: 14.136

3. Increased expression of FGF1-mediated signaling molecules in adipose tissue of obese mice.

Authors: Youngshim Choi; Suhyeon Jang; Myung-Sook Choi; Zae Young Ryoo; Taesun Park
Journal: J Physiol Biochem Date: 2016-02-04 Impact factor: 4.158

4. Overlapping mouse subcongenic strains successfully separate two linked body fat QTL on distal MMU 2.

Authors: Rodrigo Gularte-Mérida; Charles R Farber; Ricardo A Verdugo; Alma Islas-Trejo; Thomas R Famula; Craig H Warden; Juan F Medrano
Journal: BMC Genomics Date: 2015-01-23 Impact factor: 3.969

5. Large-scale gene analysis of rabbit atherosclerosis to discover new biomarkers for coronary artery disease.

Authors: Xiaolan Yu; Wen Guan; Yang Zhang; Qing Deng; Jingjing Li; Hao Ye; Shaorong Deng; Wei Han; Yan Yu
Journal: Open Biol Date: 2019-01-31 Impact factor: 6.411

6. The difference of castration timing of Korean Hanwoo bulls does not significantly affect the carcass characteristics.

Authors: Heeok Hong; Delgerzul Baatar; Seong-Gu Hwang
Journal: J Anim Sci Technol Date: 2021-03-31

7. Ethanol extract from Moringa oleifera leaves modulates brown adipose tissue and bone morphogenetic protein 7 in high-fat diet mice.

Authors: Mas Rizky A A Syamsunarno; Fenty Alia; Neni Anggraeni; Vanessa Ayu Sumirat; Suhendra Praptama; Nur Atik
Journal: Vet World Date: 2021-05-21

Review 8. Potential Functions of the BMP Family in Bone, Obesity, and Glucose Metabolism.

Authors: Yao Chen; Bingwei Ma; Xingchun Wang; Xiaojuan Zha; Chunjun Sheng; Peng Yang; Shen Qu
Journal: J Diabetes Res Date: 2021-06-23 Impact factor: 4.011

8 in total