| Literature DB >> 18950180 |
Lin Dong1, Victoria A Gordon, Rebecca L Grange, Jenny Johns, Peter G Parsons, Achim Porzelle, Paul Reddell, Heiko Schill, Craig M Williams.
Abstract
EBC-23 (2), a prostate anticancer agent, was isolated from the fruit of Cinnamomum laubatii (family Lauraceae) in the Australian tropical rainforest. Extensive NOE experiments enabled the relative stereochemistry of the proposed EBC-23 (2) structure to be determined. Total synthesis of both enantiopodes over nine linear steps, involving challenging RCM and spiroacetal cyclizations, confirmed the gross structure and relative and absolute stereochemistry.Entities:
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Year: 2008 PMID： 18950180 DOI： 10.1021/ja807133p
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419