Literature DB >> 18946840

Advances in protein therapeutics.

Gary Woodnutt1, Bernard Violand, Michael North.   

Abstract

This review summarizes recent advances in the discovery and development of novel protein therapeutics. The most advanced technology platforms currently available are highlighted and examples where novel protein scaffolds have been successfully applied to identify clinical candidates are provided. This review also examines the progress of these molecules in the clinic and discusses the advantages and disadvantages of these approaches over traditional methods.

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Year:  2008        PMID： 18946840

Source DB:  PubMed          Journal:  Curr Opin Drug Discov Devel        ISSN： 1367-6733


  7 in total

1.  Potential aggregation-prone regions in complementarity-determining regions of antibodies and their contribution towards antigen recognition: a computational analysis.

Authors:  Xiaoling Wang; Satish K Singh; Sandeep Kumar
Journal:  Pharm Res       Date:  2010-04-27       Impact factor: 4.200

2.  Structural determinants of affinity enhancement between GoLoco motifs and G-protein alpha subunit mutants.

Authors:  Dustin E Bosch; Adam J Kimple; Deanne W Sammond; Robin E Muller; Michael J Miley; Mischa Machius; Brian Kuhlman; Francis S Willard; David P Siderovski
Journal:  J Biol Chem       Date:  2010-11-29       Impact factor: 5.157

3.  Expanding the concept of chemically programmable antibodies to RNA aptamers: chemically programmed biotherapeutics.

Authors:  Ulrich Wuellner; Julia I Gavrilyuk; Carlos F Barbas
Journal:  Angew Chem Int Ed Engl       Date:  2010-08-09       Impact factor: 15.336

4.  Generation and screening of Pichia pastoris strains with enhanced protein production by use of microengraving.

Authors:  Vasiliki Panagiotou; Kerry Routenberg Love; Bo Jiang; Juergen Nett; Terrance Stadheim; J Christopher Love
Journal:  Appl Environ Microbiol       Date:  2011-03-04       Impact factor: 4.792

5.  On the way to commercializing plant cell culture platform for biopharmaceuticals: present status and prospect.

Authors:  Jianfeng Xu; Ningning Zhang
Journal:  Pharm Bioprocess       Date:  2014-12-01

6.  Chemically programmed bispecific antibodies that recruit and activate T cells.

Authors:  Huiting Cui; Joshua D Thomas; Terrence R Burke; Christoph Rader
Journal:  J Biol Chem       Date:  2012-07-03       Impact factor: 5.157

7.  The effect of protein structure on their controlled release from an injectable peptide hydrogel.

Authors:  Monica C Branco; Darrin J Pochan; Norman J Wagner; Joel P Schneider
Journal:  Biomaterials       Date:  2010-10-16       Impact factor: 12.479
  7 in total

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