Literature DB >> 18941137

A scaffold makes the switch.

Henrik G Dohlman1.   

Abstract

Protein kinase cascades are a reoccurring feature of signal transduction pathways. Recent investigations have focused on how kinase-scaffolding proteins help to convert a graded stimulus into a switch-like or binary response. New findings reveal that the graded-to-binary conversion can be turned on or off, depending on the location of the scaffold within the cell.

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Year:  2008        PMID： 18941137     DOI： 10.1126/scisignal.142pe46

Source DB:  PubMed          Journal:  Sci Signal        ISSN： 1945-0877            Impact factor:   8.192


  9 in total

1.  Amplification of signaling via cellular allosteric relay and protein disorder.

Authors:  Buyong Ma; Ruth Nussinov
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-22       Impact factor: 11.205

2.  GTP-dependent scaffold formation in the GTPase of Immunity Associated Protein family.

Authors:  David Schwefel; Oliver Daumke
Journal:  Small GTPases       Date:  2011-01

3.  MAPK feedback encodes a switch and timer for tunable stress adaptation in yeast.

Authors:  Justin G English; James P Shellhammer; Michael Malahe; Patrick C McCarter; Timothy C Elston; Henrik G Dohlman
Journal:  Sci Signal       Date:  2015-01-13       Impact factor: 8.192

Review 4.  CheV: CheW-like coupling proteins at the core of the chemotaxis signaling network.

Authors:  Roger P Alexander; Andrew C Lowenthal; Rasika M Harshey; Karen M Ottemann
Journal:  Trends Microbiol       Date:  2010-09-09       Impact factor: 17.079

5.  Inhibition of EGF-induced ERK/MAP kinase-mediated astrocyte proliferation by mu opioids: integration of G protein and beta-arrestin 2-dependent pathways.

Authors:  Mayumi Miyatake; Tal J Rubinstein; Gregory P McLennan; Mariana M Belcheva; Carmine J Coscia
Journal:  J Neurochem       Date:  2009-05-08       Impact factor: 5.372

6.  Signal response sensitivity in the yeast mitogen-activated protein kinase cascade.

Authors:  Craig J Thalhauser; Natalia L Komarova
Journal:  PLoS One       Date:  2010-07-23       Impact factor: 3.240

7.  Shoc2 is targeted to late endosomes and required for Erk1/2 activation in EGF-stimulated cells.

Authors:  Emilia Galperin; Lina Abdelmoti; Alexander Sorkin
Journal:  PLoS One       Date:  2012-05-14       Impact factor: 3.240

Review 8.  Beta-Adrenergic Agonists.

Authors:  Giovanni Barisione; Michele Baroffio; Emanuele Crimi; Vito Brusasco
Journal:  Pharmaceuticals (Basel)       Date:  2010-03-30

Review 9.  Small molecule substrate phosphorylation site inhibitors of protein kinases: approaches and challenges.

Authors:  Meghan E Breen; Matthew B Soellner
Journal:  ACS Chem Biol       Date:  2014-12-23       Impact factor: 5.100
  9 in total

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