Literature DB >> 18939802

Rapid enantiomeric excess and concentration determination using simple racemic metal complexes.

Sonia Nieto1, Vincent M Lynch, Eric V Anslyn, Hyunwoo Kim, Jik Chin.   

Abstract

Racemic-metal complexes were used to determine identity, enantiomeric excess, and concentration of chiral diamines using metal-to-ligand charge transfer bands in circular dichroism spectroscopy. It takes under just 2 min per sample to determine [G]t and %R with tolerable errors (19% and 4%, respectively). The simplicity of the achiral receptors employed confers to this technique great potential for high-throughput screening.

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Year:  2008        PMID： 18939802      PMCID： PMC2749327          DOI： 10.1021/ol802085j

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  30 in total

Review 1.  High-throughput screening for biocatalysts.

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Journal:  Curr Opin Biotechnol       Date:  2001-12       Impact factor: 9.740

2.  A multicomponent sensing ensemble in solution: differentiation between structurally similar analytes.

Authors:  Sheryl L Wiskur; Pierre N Floriano; Eric V Anslyn; John T McDevitt
Journal:  Angew Chem Int Ed Engl       Date:  2003-05-09       Impact factor: 15.336

3.  High-throughput measurement of the enantiomeric excess of chiral alcohols by using two enzymes.

Authors:  Zhi Li; Lukas Bütikofer; Bernard Witholt
Journal:  Angew Chem Int Ed Engl       Date:  2004-03-19       Impact factor: 15.336

4.  Design and DNA binding of an extended triple-stranded metallo-supramolecular cylinder.

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Journal:  Chemistry       Date:  2005-03-04       Impact factor: 5.236

5.  Pattern-based discrimination of enantiomeric and structurally similar amino acids: an optical mimic of the mammalian taste response.

Authors:  J Frantz Folmer-Andersen; Masanori Kitamura; Eric V Anslyn
Journal:  J Am Chem Soc       Date:  2006-05-03       Impact factor: 15.419

Review 6.  Circular dichroism of biological macromolecules.

Authors:  S Beychok
Journal:  Science       Date:  1966-12-09       Impact factor: 47.728

7.  Colorimetric enantiodiscrimination of alpha-amino acids in protic media.

Authors:  J Frantz Folmer-Andersen; Vincent M Lynch; Eric V Anslyn
Journal:  J Am Chem Soc       Date:  2005-06-08       Impact factor: 15.419

8.  Fluorescence sensing of ammonium and organoammonium ions with tripodal oxazoline receptors.

Authors:  Kyo Han Ahn; Hui-Young Ku; Yusin Kim; Sung-Gon Kim; Young Kook Kim; Hyung Su Son; Ja Kang Ku
Journal:  Org Lett       Date:  2003-05-01       Impact factor: 6.005

9.  Facile quantification of enantiomeric excess and concentration with indicator-displacement assays: an example in the analyses of alpha-hydroxyacids.

Authors:  Lei Zhu; Eric V Anslyn
Journal:  J Am Chem Soc       Date:  2004-03-31       Impact factor: 15.419

10.  Chirality sensing with synthetic pores.

Authors:  Hiroyuki Tanaka; Stefan Matile
Journal:  Chirality       Date:  2008-03       Impact factor: 2.437
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  10 in total

1.  In situ assembly of octahedral Fe(II) complexes for the enantiomeric excess determination of chiral amines using circular dichroism spectroscopy.

Authors:  Justin M Dragna; Gennaro Pescitelli; Lee Tran; Vincent M Lynch; Eric V Anslyn; Lorenzo Di Bari
Journal:  J Am Chem Soc       Date:  2012-02-22       Impact factor: 15.419

2.  An ESI-MS method to determine yield and enantioselectivity in a single assay.

Authors:  Maureen E Smith; Steven A Knolls; MyLe Thompson; Douglas S Masterson
Journal:  J Am Soc Mass Spectrom       Date:  2014-12-16       Impact factor: 3.109

3.  Rapid determination of enantiomeric excess of α-chiral cyclohexanones using circular dichroism spectroscopy.

Authors:  Diana Leung; Eric V Anslyn
Journal:  Org Lett       Date:  2011-04-12       Impact factor: 6.005

4.  Chiral discrimination of α-hydroxy acids and N-Ts-α-amino acids induced by tetraaza macrocyclic chiral solvating agents by using 1H NMR spectroscopy.

Authors:  Caixia Lv; Lei Feng; Hongmei Zhao; Guo Wang; Pericles Stavropoulos; Lin Ai
Journal:  Org Biomol Chem       Date:  2017-01-27       Impact factor: 3.876

5.  A simple method for the determination of enantiomeric excess and identity of chiral carboxylic acids.

Authors:  Leo A Joyce; Marc S Maynor; Justin M Dragna; Gabriella M da Cruz; Vincent M Lynch; James W Canary; Eric V Anslyn
Journal:  J Am Chem Soc       Date:  2011-08-03       Impact factor: 15.419

6.  A facile circular dichroism protocol for rapid determination of enantiomeric excess and concentration of chiral primary amines.

Authors:  Sonia Nieto; Justin M Dragna; Eric V Anslyn
Journal:  Chemistry       Date:  2010-01-04       Impact factor: 5.236

7.  Synthesis of Tripeptide Derivatives with Three Stereogenic Centers and Chiral Recognition Probed by Tetraaza Macrocyclic Chiral Solvating Agents Derived from d-Phenylalanine and (1 S,2 S)-(+)-1,2-Diaminocyclohexane via 1H NMR Spectroscopy.

Authors:  Lei Feng; Guangpeng Gao; Hongmei Zhao; Li Zheng; Yu Wang; Pericles Stavropoulos; Lin Ai; Jiaxin Zhang
Journal:  J Org Chem       Date:  2018-10-30       Impact factor: 4.354

Review 8.  Chiroptical switches: applications in sensing and catalysis.

Authors:  Zhaohua Dai; Jennifer Lee; Wenyao Zhang
Journal:  Molecules       Date:  2012-01-31       Impact factor: 4.411

9.  Rapid organocatalytic chirality analysis of amines, amino acids, alcohols, amino alcohols and diols with achiral iso(thio)cyanate probes.

Authors:  Eryn Nelson; Jeffrey S S K Formen; C Wolf
Journal:  Chem Sci       Date:  2021-05-25       Impact factor: 9.825

10.  Discrimination of enantiomers of amides with two stereogenic centers enabled by chiral bisthiourea derivatives using 1H NMR spectroscopy.

Authors:  Hanchang Zhang; Hongmei Zhao; Jie Wen; Zhanbin Zhang; Pericles Stavropoulos; Yanlin Li; Lin Ai; Jiaxin Zhang
Journal:  Org Biomol Chem       Date:  2021-08-05       Impact factor: 3.890
  10 in total

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