Literature DB >> 15038696

Facile quantification of enantiomeric excess and concentration with indicator-displacement assays: an example in the analyses of alpha-hydroxyacids.

Lei Zhu1, Eric V Anslyn.   

Abstract

An enantioselective indicator-displacement assay was developed to determine enantiomeric excess (ee) and concentration of alpha-hydroxyacid samples with two independent absorption measurements. The inherent relationship between the absorbance of the indicator-displacement ensemble and the overall concentration and ee of the analyte was established through solution equilibria.

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Year:  2004        PMID： 15038696     DOI： 10.1021/ja031839s

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  13 in total

1.  Algorithms for the determination of binding constants and enantiomeric excess in complex host : guest equilibria using optical measurements.

Authors:  Amanda E Hargrove; Zhenlin Zhong; Jonathan L Sessler; Eric V Anslyn
Journal:  New J Chem       Date:  2010       Impact factor: 3.591

2.  High-throughput screening of identity, enantiomeric excess, and concentration using MLCT transitions in CD spectroscopy.

Authors:  Sonia Nieto; Vincent M Lynch; Eric V Anslyn; Hyunwoo Kim; Jik Chin
Journal:  J Am Chem Soc       Date:  2008-06-24       Impact factor: 15.419

3.  An ESI-MS method to determine yield and enantioselectivity in a single assay.

Authors:  Maureen E Smith; Steven A Knolls; MyLe Thompson; Douglas S Masterson
Journal:  J Am Soc Mass Spectrom       Date:  2014-12-16       Impact factor: 3.109

Review 4.  Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids.

Authors:  Joana Krämer; Rui Kang; Laura M Grimm; Luisa De Cola; Pierre Picchetti; Frank Biedermann
Journal:  Chem Rev       Date:  2022-01-07       Impact factor: 60.622

5.  A facile circular dichroism protocol for rapid determination of enantiomeric excess and concentration of chiral primary amines.

Authors:  Sonia Nieto; Justin M Dragna; Eric V Anslyn
Journal:  Chemistry       Date:  2010-01-04       Impact factor: 5.236

6.  Pattern-based recognition for the rapid determination of identity, concentration, and enantiomeric excess of subtly different threo diols.

Authors:  Shagufta H Shabbir; Leo A Joyce; Gabriella M da Cruz; Vincent M Lynch; Steven Sorey; Eric V Anslyn
Journal:  J Am Chem Soc       Date:  2009-09-16       Impact factor: 15.419

7.  Rapid enantiomeric excess and concentration determination using simple racemic metal complexes.

Authors:  Sonia Nieto; Vincent M Lynch; Eric V Anslyn; Hyunwoo Kim; Jik Chin
Journal:  Org Lett       Date:  2008-10-22       Impact factor: 6.005

8.  Molecular recognition and self-assembly special feature: A general protocol for creating high-throughput screening assays for reaction yield and enantiomeric excess applied to hydrobenzoin.

Authors:  Shagufta H Shabbir; Clinton J Regan; Eric V Anslyn
Journal:  Proc Natl Acad Sci U S A       Date:  2009-03-30       Impact factor: 11.205

9.  Sequencing and characterization of oligosaccharides using infrared multiphoton dissociation and boronic acid derivatization in a quadrupole ion trap.

Authors:  Michael Pikulski; Amanda Hargrove; Shagufta H Shabbir; Eric V Anslyn; Jennifer S Brodbelt
Journal:  J Am Soc Mass Spectrom       Date:  2007-09-14       Impact factor: 3.109

10.  Rapid organocatalytic chirality analysis of amines, amino acids, alcohols, amino alcohols and diols with achiral iso(thio)cyanate probes.

Authors:  Eryn Nelson; Jeffrey S S K Formen; C Wolf
Journal:  Chem Sci       Date:  2021-05-25       Impact factor: 9.825
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