Literature DB >> 18937484

Functionalized analogues of an unnatural amino acid that mimics a tripeptide beta-strand.

Tatyana V Khasanova1, Omid Khakshoor, James S Nowick.   

Abstract

This paper introduces polar and hydrophobic variants of the unnatural amino acid Hao, which mimics the hydrogen-bonding functionality of one edge of a beta-strand. In these variants, the methyl side chain of Hao is replaced with acidic, basic, and hydrophobic groups. These modifications can impart improved solubility and additional side-chain interactions to peptides containing Hao.

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Year:  2008        PMID： 18937484      PMCID： PMC2659333          DOI： 10.1021/ol8021897

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  22 in total

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Review 2.  Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.

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