INTRODUCTION: Asthma is one of the most common chronic diseases in children. It is caused by complex interactions between various genetic factors and exposures to environmental allergens and irritants. Because of the heterogeneity of the disease and the genetic and cultural differences among different populations, a proper association study and genetic testing for asthma and susceptibility genes is difficult to perform. MATERIALS AND METHODS: We assessed 13 single-nucleotide polymorphisms (SNPs) in seven well-known asthma susceptibility genes and looked for association with pediatric asthma using 449 asthmatic subjects and 512 non-asthma subjects in Taiwanese population. RESULTS: CD14-159 C/T and MS4A2 Glu237Gly were identified to have difference in genotype/allele frequencies between the control group and asthma patients. Moreover, the genotype synergistic analysis showed that the co-contribution of two functional SNPs was riskier or more protective from asthma attack. Our study provided a genotype synergistic method for studying gene-gene interaction on polymorphism basis and genetic testing using multiple polymorphisms.
INTRODUCTION:Asthma is one of the most common chronic diseases in children. It is caused by complex interactions between various genetic factors and exposures to environmental allergens and irritants. Because of the heterogeneity of the disease and the genetic and cultural differences among different populations, a proper association study and genetic testing for asthma and susceptibility genes is difficult to perform. MATERIALS AND METHODS: We assessed 13 single-nucleotide polymorphisms (SNPs) in seven well-known asthma susceptibility genes and looked for association with pediatric asthma using 449 asthmatic subjects and 512 non-asthma subjects in Taiwanese population. RESULTS:CD14-159 C/T and MS4A2 Glu237Gly were identified to have difference in genotype/allele frequencies between the control group and asthmapatients. Moreover, the genotype synergistic analysis showed that the co-contribution of two functional SNPs was riskier or more protective from asthma attack. Our study provided a genotype synergistic method for studying gene-gene interaction on polymorphism basis and genetic testing using multiple polymorphisms.
Authors: H Hakonarson; U S Bjornsdottir; E Ostermann; T Arnason; A E Adalsteinsdottir; E Halapi; D Shkolny; K Kristjansson; S A Gudnadottir; M L Frigge; D Gislason; T Gislason; A Kong; J Gulcher; K Stefansson Journal: Am J Respir Crit Care Med Date: 2001-12-01 Impact factor: 21.405
Authors: Iris H S Chan; Ting F Leung; Nelson L S Tang; Chung Y Li; Ying M Sung; Gary W K Wong; Chun K Wong; Christopher W K Lam Journal: J Allergy Clin Immunol Date: 2005-12-02 Impact factor: 10.793
Authors: Xiaobo Li; Yonggang Zhang; Jie Zhang; Yuling Xiao; Jin Huang; Can Tian; Chao He; Yao Deng; Yingying Yang; Hong Fan Journal: Respir Res Date: 2010-09-24