Literature DB >> 189311

The humoral immune response of NIH Swiss and SWR/J mice to vaccination with formalinized AKR or Gross murine leukemia virus.

J C Lee, J N Ihle, R Huebner.   

Abstract

The humoral immune responses of NIH Swiss and SWR/J mice immunized with formalin-inactivated AKR or Gross murine leukemia virus, respectively, were examined. Both immune sera had high titers of antibodies detectable in radioimmune precipitation assays using [3H]leucine-labeled AKR virus and in radioimmunoassays using purified virion components. The predominant antibody titers were directed against gp71 and pl15(E). The immune response against gp71 was predominantly type-specific, whereas the reactivity with pl15(E) was predominantly group-specific. A weak immune response against p15 was also detected. Both sera were cytotoxic against cells replicating the AKR-Gross virus type but not against cells replicating Friend murine leukemia virus. This cytotoxicity could be specifically blocked with purified gp71 of AKR murine leukemia virus. Sera from immune NIH Swiss mice neutralized AKR virus, but did not neutralize Rauscher, Scripps, or wild mouse leukemia virus.

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Year:  1977        PMID： 189311      PMCID： PMC393256          DOI： 10.1073/pnas.74.1.343

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

1.  IMMUNE REACTIONS TO A MURINE LEUKEMIA VIRUS. I. INDUCTION OF IMMUNITY TO INFECTION WITH VIRUS IN THE NATURAL HOST.

Authors:  M A FINK; F J RAUSCHER
Journal:  J Natl Cancer Inst       Date:  1964-05       Impact factor: 13.506

2.  Naturally occurring cytotoxic tumour reactive antibodies directed against type C viral envelope antigens.

Authors:  S E Martin; W J Martin
Journal:  Nature       Date:  1975-08-07       Impact factor: 49.962

3.  Chromatographic separation and antigenic analysis of proteins of the oncornaviruses. V. Identification of a new murine viral protein, p15(E).

Authors:  H Ikeda; W Hardy; E Tress; E Fleissner
Journal:  J Virol       Date:  1975-07       Impact factor: 5.103

4.  Pathogenic properties, and "vertical" transmission of the mouse leukemia agent.

Authors:  L GROSS
Journal:  Proc Soc Exp Biol Med       Date:  1951-10

5.  Properties of mouse leukemia viruses. IX. Active and passive immunization of mice against Friend leukemia with isolated viral GP71 glycoprotein and its corresponding antiserum.

Authors:  G Hunsmann; V Moennig; W Schäfer
Journal:  Virology       Date:  1975-07       Impact factor: 3.616

6.  The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.

Authors:  K Weber; M Osborn
Journal:  J Biol Chem       Date:  1969-08-25       Impact factor: 5.157

7.  Characterization of the type and group specificities of the immune response in mice to murine leukemia viruses.

Authors:  J N Ihle; J J Domotor; K M Bengali
Journal:  J Virol       Date:  1976-04       Impact factor: 5.103

8.  Structural proteins of mammalian oncogenic RNA viruses: murine leukemia virus neutralization by antisera prepared against purified envelope glycoprotein.

Authors:  R A Steeves; M Strand; J T August
Journal:  J Virol       Date:  1974-07       Impact factor: 5.103

9.  Properties of mouse leukemia viruses. VIII. The major viral glycoprotein of Friend leukemia virus. Seroimmunological, interfering and hemagglutinating capacities.

Authors:  G Hunsmann; V Moennig; L Pister; E Seifert; W Schäfer
Journal:  Virology       Date:  1974-12       Impact factor: 3.616

10.  Autogenous immunity to endogenous RNA tumor virus. Radioimmune precipitation assay of mouse serum antibody levels.

Authors:  J N Ihle; M Yurconic; M G Hanna
Journal:  J Exp Med       Date:  1973-07-01       Impact factor: 14.307
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  4 in total

1.  H-2-mediated resistance to an ecotropic type C retrovirus: localization of controlling genes and ontogenic studies of resistance.

Authors:  S E Bear; P N Tsichlis; R S Schwartz
Journal:  Immunogenetics       Date:  1980       Impact factor: 2.846

Review 2.  Infection barriers to successful xenotransplantation focusing on porcine endogenous retroviruses.

Authors:  Joachim Denner; Ralf R Tönjes
Journal:  Clin Microbiol Rev       Date:  2012-04       Impact factor: 26.132

3.  Immunoprevention of x-ray-induced leukemias in the C57BL mouse.

Authors:  R L Peters; B Sass; J R Stephenson; I K Al-Ghazzouli; S Hino; R M Donahoe; M Kende; S A Aaronson; G J KElloff
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205

4.  Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies.

Authors:  Xiaoxing Qiu; Priscilla Swanson; Ka-Cheung Luk; Bailin Tu; Francois Villinger; Jaydip Das Gupta; Robert H Silverman; Eric A Klein; Sushil Devare; Gerald Schochetman; John Hackett
Journal:  Retrovirology       Date:  2010-08-17       Impact factor: 4.602
  4 in total

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