OBJECTIVE: To determine the effect of treatment with vitamin D(3) analogue in the parameters of glucose metabolism in obese women with polycystic ovary syndrome (PCOS). DESIGN: Observational study. SETTING: Obese women with PCOS in an academic research environment. PATIENT(S): Fifteen obese women (mean age 28 +/- 1.3 years, mean body mass index 32.55 +/- 0.43) with documented chronic anovulation and hyperandrogenism were recruited into the study. INTERVENTION(S): Alphacalcidol (1-alpha-hydroxyvitamin D(3)) was administered orally 1 microg/day for 3 months. All subjects underwent a frequently sampled IV glucose tolerance test after a 10- to 12-hour overnight fast during a spontaneous bleeding episode before and after treatment with alphacalcidol. MAIN OUTCOME MEASURE(S): Peripheral insulin resistance and insulin effectiveness were estimated with minimal model. RESULT(S): The first phase of insulin secretion was significantly increased after treatment with alphacalcidol. A favorable statistically significant change also was observed in the lipid profile. CONCLUSION(S): Treatment with the vitamin D(3) analogue (alphacalcidol) could be of value in the management of PCOS.
OBJECTIVE: To determine the effect of treatment with vitamin D(3) analogue in the parameters of glucose metabolism in obesewomen with polycystic ovary syndrome (PCOS). DESIGN: Observational study. SETTING:Obesewomen with PCOS in an academic research environment. PATIENT(S): Fifteen obesewomen (mean age 28 +/- 1.3 years, mean body mass index 32.55 +/- 0.43) with documented chronic anovulation and hyperandrogenism were recruited into the study. INTERVENTION(S): Alphacalcidol (1-alpha-hydroxyvitamin D(3)) was administered orally 1 microg/day for 3 months. All subjects underwent a frequently sampled IV glucose tolerance test after a 10- to 12-hour overnight fast during a spontaneous bleeding episode before and after treatment with alphacalcidol. MAIN OUTCOME MEASURE(S): Peripheral insulin resistance and insulin effectiveness were estimated with minimal model. RESULT(S): The first phase of insulin secretion was significantly increased after treatment with alphacalcidol. A favorable statistically significant change also was observed in the lipid profile. CONCLUSION(S): Treatment with the vitamin D(3) analogue (alphacalcidol) could be of value in the management of PCOS.
Authors: Jin Ju Kim; Young Min Choi; Soo Jin Chae; Kyu Ri Hwang; Sang Ho Yoon; Min Jeong Kim; Sun Mie Kim; Seung Yup Ku; Seok Hyun Kim; Jung Gu Kim Journal: Clin Exp Reprod Med Date: 2014-06-30