| Literature DB >> 18926700 |
Angel I Morales-Ramos1, John S Mecom, Terry J Kiesow, Todd L Graybill, Gregory D Brown, Nambi V Aiyar, Elizabeth A Davenport, Lorena A Kallal, Beth A Knapp-Reed, Peng Li, Allyn T Londregan, Dwight M Morrow, Shobha Senadhi, Reema K Thalji, Steve Zhao, Cynthia L Burns-Kurtis, Joseph P Marino.
Abstract
High-throughput screening of the GSK compound collection against the P2Y(1) receptor identified a novel series of tetrahydro-4-quinolinamine antagonists. Optimal substitution around the piperidine group was pivotal for ensuring activity. An exemplar analog from this series was shown to inhibit platelet aggregation.Entities:
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Year: 2008 PMID： 18926700 DOI： 10.1016/j.bmcl.2008.09.102
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823