BACKGROUND: The aim of this study is to determine whether B12 replacement would ameliorate cognitive and psychiatric symptoms in elderly subjects with dementia and low serum B12 levels. METHODS: A test group (n = 28) of nursing home residents with low serum B12 levels (<250 pg/mL) and a matched comparison group (n = 28) with normal serum B12 levels (>300 pg/mL) were evaluated by blinded raters while the test group received intramuscular (IM) B12 replacement therapy. All subjects were assessed at baseline, 8 weeks, and 16 weeks with the Dementia Rating Scale, Brief Psychiatric Rating Scale, and Geriatric Depression Scale. RESULTS: Although B12 replacement produced significant improvement in hematologic and metabolic parameters, it yielded no significant effect on cognitive or psychiatric variables. A few subjects evidenced notable individual treatment responses; however, these were not statistically more frequent than in the normal B12 group. CONCLUSIONS: These results suggest that B12 replacement is unlikely to benefit cognitive or psychiatric symptoms in the vast majority of elderly dementia patients with low serum B12 levels.
BACKGROUND: The aim of this study is to determine whether B12 replacement would ameliorate cognitive and psychiatric symptoms in elderly subjects with dementia and low serum B12 levels. METHODS: A test group (n = 28) of nursing home residents with low serum B12 levels (<250 pg/mL) and a matched comparison group (n = 28) with normal serum B12 levels (>300 pg/mL) were evaluated by blinded raters while the test group received intramuscular (IM) B12 replacement therapy. All subjects were assessed at baseline, 8 weeks, and 16 weeks with the Dementia Rating Scale, Brief Psychiatric Rating Scale, and Geriatric Depression Scale. RESULTS: Although B12 replacement produced significant improvement in hematologic and metabolic parameters, it yielded no significant effect on cognitive or psychiatric variables. A few subjects evidenced notable individual treatment responses; however, these were not statistically more frequent than in the normal B12 group. CONCLUSIONS: These results suggest that B12 replacement is unlikely to benefit cognitive or psychiatric symptoms in the vast majority of elderly dementiapatients with low serum B12 levels.
Authors: Peter V Rabins; Deborah Blacker; Barry W Rovner; Teresa Rummans; Lon S Schneider; Pierre N Tariot; David M Blass; John S McIntyre; Sara C Charles; Daniel J Anzia; Ian A Cook; Molly T Finnerty; Bradley R Johnson; James E Nininger; Barbara Schneidman; Paul Summergrad; Sherwyn M Woods; Joseph Berger; C Deborah Cross; Harry A Brandt; Philip M Margolis; John P D Shemo; Barton J Blinder; David L Duncan; Mary Ann Barnovitz; Anthony J Carino; Zachary Z Freyberg; Sheila Hafter Gray; Tina Tonnu; Robert Kunkle; Amy B Albert; Thomas J Craig; Darrel A Regier; Laura J Fochtmann Journal: Am J Psychiatry Date: 2007-12 Impact factor: 18.112
Authors: Círia Pereira; Victor Chavarria; João Vian; Melanie Maree Ashton; Michael Berk; Wolfgang Marx; Olivia May Dean Journal: Int J Neuropsychopharmacol Date: 2018-06-01 Impact factor: 5.176
Authors: Anna Andrea Lauer; Heike Sabine Grimm; Birgit Apel; Nataliya Golobrodska; Lara Kruse; Elina Ratanski; Noemi Schulten; Laura Schwarze; Thomas Slawik; Saskia Sperlich; Antonia Vohla; Marcus Otto Walter Grimm Journal: Biomolecules Date: 2022-01-14