Literature DB >> 1888990

Characterization of muscarinic receptor subtype of rat eccrine sweat gland by autoradiography.

N E Torres1, P J Zollman, P A Low.   

Abstract

The muscarinic cholinergic receptor of rat eccrine sweat gland was characterized using quantitative autoradiography and [3H]QNB as radioligand. The distribution of radioligand was maximal in the secretory coil. Autoradiographic competition binding studies were performed using selective antagonists to M1 (pirenzepine), M2 (AF-DX 116), and M3 (4-DAMP) and the classical nonselective antagonist atropine. pKi for pirenzepine, AF-DX 116, 4-DAMP, and atropine was 6.58, 5.47, 8.50, and 8.66 respectively indicating that the eccrine sweat gland muscarinic receptor was predominantly M3.

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Year:  1991        PMID： 1888990     DOI： 10.1016/0006-8993(91)90415-r

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2014-04-29       Impact factor: 11.205

2.  Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function.

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Review 3.  Regulation of epithelial ion transport in exocrine glands by store-operated Ca2+ entry.

Authors:  Axel R Concepcion; Stefan Feske
Journal:  Cell Calcium       Date:  2016-12-21       Impact factor: 6.817

4.  Cutaneous blood flow and sweat rate responses to exogenous administration of acetylcholine and methacholine.

Authors:  Kenichi Kimura; David A Low; David M Keller; Scott L Davis; Craig G Crandall
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Review 5.  Eccrine sweat gland development and sweat secretion.

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Journal:  Exp Dermatol       Date:  2015-07-14       Impact factor: 3.960

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7.  The effects of vasoactive intestinal polypeptide and substance P on methacholine-induced sweating and vascular flare in diabetic neuropathy.

Authors:  T J Berg; D M Levy; G Reid; R R Abraham
Journal:  Clin Auton Res       Date:  1995-06       Impact factor: 4.435

Review 8.  Drug-induced hyperhidrosis and hypohidrosis: incidence, prevention and management.

Authors:  William P Cheshire; Robert D Fealey
Journal:  Drug Saf       Date:  2008       Impact factor: 5.606

9.  Characterization of methanthelinium binding and function at human M1-M5 muscarinic acetylcholine receptors.

Authors:  Matthias Irmen; Janine Holze; Theresa Bödefeld; Christian Tränkle
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2018-06-24       Impact factor: 3.000
  9 in total

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