| Literature DB >> 1886615 |
J Rakonjac1, M Milic, D J Savic.
Abstract
Mutations in the cysB and cysE genes of Escherichia coli K12 cause an increase in resistance to the gyrase inhibitor novobiocin but not to coumermycin, acriflavine and rifampicin. This unusual relationship was also observed among spontaneous novobiocin resistant (Novr) mutants: 10% of Novr mutants isolated on rich (LA) plates with novobiocin could not grow on minimal plates, and among those approximately half were cysB or cysE mutants. Further analyses demonstrated that cysB and cysE negative alleles neither interfere with transport of novobiocin nor affect DNA supercoiling.Entities:
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Year: 1991 PMID： 1886615 DOI： 10.1007/bf00282481
Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925