Literature DB >> 18854599

Expression of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma.

Joana Gomes1, Nuno T Marcos, Nora Berois, Eduardo Osinaga, Ana Magalhães, João Pinto-de-Sousa, Raquel Almeida, Fátima Gärtner, Celso A Reis.   

Abstract

Aberrant mucin O-glycosylation is often observed in cancer and is characterized by the expression of immature simple mucin-type carbohydrate antigens. UDP-N-acetyl-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase-6 (ppGalNAc-T6) is one of the enzymes responsible for the initial step in O-glycosylation. This study evaluated the expression of ppGalNAc-T6 in human gastric mucosa, intestinal metaplasia, and gastric carcinomas. Our results showed that ppGalNAc-T6 is expressed in normal gastric mucosa and in intestinal metaplasia. A heterogeneous expression and staining pattern for this enzyme was observed in gastric carcinomas. ppGalNAc-T6 was expressed in 79% of the cases, and its expression level was associated with the presence of venous invasion. Our results provide evidence that ppGalNAc-T6 is an IHC marker associated with venous invasion in gastric carcinoma and may contribute to the understanding of the molecular mechanisms that underlie aberrant glycosylation in gastric carcinogenesis and in gastric carcinoma.

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Year:  2008        PMID： 18854599      PMCID： PMC2605713          DOI： 10.1369/jhc.2008.952283

Source DB:  PubMed          Journal:  J Histochem Cytochem        ISSN： 0022-1554            Impact factor:   2.479


  49 in total

1.  THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION.

Authors:  P LAUREN
Journal:  Acta Pathol Microbiol Scand       Date:  1965

2.  Cloning and expression of a novel, tissue specifically expressed member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family.

Authors:  K G Ten Hagen; F K Hagen; M M Balys; T M Beres; B Van Wuyckhuyse; L A Tabak
Journal:  J Biol Chem       Date:  1998-10-16       Impact factor: 5.157

3.  Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3.

Authors:  H H Wandall; H Hassan; E Mirgorodskaya; A K Kristensen; P Roepstorff; E P Bennett; P A Nielsen; M A Hollingsworth; J Burchell; J Taylor-Papadimitriou; H Clausen
Journal:  J Biol Chem       Date:  1997-09-19       Impact factor: 5.157

4.  Expression of three UDP-N-acetyl-alpha-D-galactosamine:polypeptide GalNAc N-acetylgalactosaminyltransferases in adenocarcinoma cell lines.

Authors:  M E Sutherlin; I Nishimori; T Caffrey; E P Bennett; H Hassan; U Mandel; D Mack; T Iwamura; H Clausen; M A Hollingsworth
Journal:  Cancer Res       Date:  1997-11-01       Impact factor: 12.701

5.  Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression.

Authors:  C A Reis; L David; P Correa; F Carneiro; C de Bolós; E Garcia; U Mandel; H Clausen; M Sobrinho-Simões
Journal:  Cancer Res       Date:  1999-03-01       Impact factor: 12.701

6.  Characterization of a UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase that displays glycopeptide N-acetylgalactosaminyltransferase activity.

Authors:  K G Ten Hagen; D Tetaert; F K Hagen; C Richet; T M Beres; J Gagnon; M M Balys; B VanWuyckhuyse; G S Bedi; P Degand; L A Tabak
Journal:  J Biol Chem       Date:  1999-09-24       Impact factor: 5.157

7.  Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy.

Authors:  E P Bennett; H Hassan; U Mandel; M A Hollingsworth; N Akisawa; Y Ikematsu; G Merkx; A G van Kessel; S Olofsson; H Clausen
Journal:  J Biol Chem       Date:  1999-09-03       Impact factor: 5.157

8.  Expression of polypeptide GalNAc-transferases in stratified epithelia and squamous cell carcinomas: immunohistological evaluation using monoclonal antibodies to three members of the GalNAc-transferase family.

Authors:  U Mandel; H Hassan; M H Therkildsen; J Rygaard; M H Jakobsen; B R Juhl; E Dabelsteen; H Clausen
Journal:  Glycobiology       Date:  1999-01       Impact factor: 4.313

9.  Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat.

Authors:  E P Bennett; H Hassan; U Mandel; E Mirgorodskaya; P Roepstorff; J Burchell; J Taylor-Papadimitriou; M A Hollingsworth; G Merkx; A G van Kessel; H Eiberg; R Steffensen; H Clausen
Journal:  J Biol Chem       Date:  1998-11-13       Impact factor: 5.157

10.  Expression of fully and under-glycosylated forms of MUC1 mucin in gastric carcinoma.

Authors:  C A Reis; L David; M Seixas; J Burchell; M Sobrinho-Simões
Journal:  Int J Cancer       Date:  1998-08-21       Impact factor: 7.396
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  30 in total

Review 1.  Simple sugars to complex disease--mucin-type O-glycans in cancer.

Authors:  Matthew R Kudelka; Tongzhong Ju; Jamie Heimburg-Molinaro; Richard D Cummings
Journal:  Adv Cancer Res       Date:  2015-02-07       Impact factor: 6.242

2.  De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium.

Authors:  Kirstine Lavrsen; Sally Dabelsteen; Sergey Y Vakhrushev; Asha M R Levann; Amalie Dahl Haue; August Dylander; Ulla Mandel; Lars Hansen; Morten Frödin; Eric P Bennett; Hans H Wandall
Journal:  J Biol Chem       Date:  2017-11-29       Impact factor: 5.157

Review 3.  Protein glycosylation in cancer.

Authors:  Sean R Stowell; Tongzhong Ju; Richard D Cummings
Journal:  Annu Rev Pathol       Date:  2015       Impact factor: 23.472

Review 4.  Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family.

Authors:  Eric P Bennett; Ulla Mandel; Henrik Clausen; Thomas A Gerken; Timothy A Fritz; Lawrence A Tabak
Journal:  Glycobiology       Date:  2011-12-18       Impact factor: 4.313

5.  Revisiting the human polypeptide GalNAc-T1 and T13 paralogs.

Authors:  María Florencia Festari; Felipe Trajtenberg; Nora Berois; Sergio Pantano; Leslie Revoredo; Yun Kong; Patricia Solari-Saquieres; Yoshiki Narimatsu; Teresa Freire; Sylvie Bay; Carlos Robello; Jean Bénard; Thomas A Gerken; Henrik Clausen; Eduardo Osinaga
Journal:  Glycobiology       Date:  2016-11-22       Impact factor: 4.313

6.  GalNAc-T6 in the relationship with invasion ability of endometrial carcinomas and prognostic significance.

Authors:  Thuy Thi Nguyen; Tomoko Kurita; Chiho Koi; Midori Murakami; Seiji Kagami; Toru Hachisuga; Hisaoka Masanori; Yasuo Morimoto; Hiroto Izumi
Journal:  Am J Cancer Res       Date:  2017-05-01       Impact factor: 6.166

Review 7.  Glycosylation in cancer: mechanisms and clinical implications.

Authors:  Salomé S Pinho; Celso A Reis
Journal:  Nat Rev Cancer       Date:  2015-08-20       Impact factor: 60.716

8.  Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells.

Authors:  Katrine T-B G Schjoldager; Sergey Y Vakhrushev; Yun Kong; Catharina Steentoft; Aaron S Nudelman; Nis B Pedersen; Hans H Wandall; Ulla Mandel; Eric P Bennett; Steven B Levery; Henrik Clausen
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-07       Impact factor: 11.205

Review 9.  Glycosylation Changes in Brain Cancer.

Authors:  Lucas Veillon; Christina Fakih; Hadi Abou-El-Hassan; Firas Kobeissy; Yehia Mechref
Journal:  ACS Chem Neurosci       Date:  2017-11-07       Impact factor: 4.418

10.  Use of lectin microarray to differentiate gastric cancer from gastric ulcer.

Authors:  Wei-Li Huang; Yang-Guang Li; Yong-Chen Lv; Xiao-Hui Guan; Hui-Fan Ji; Bao-Rong Chi
Journal:  World J Gastroenterol       Date:  2014-05-14       Impact factor: 5.742
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