Literature DB >> 18851910

Open-chain half-bastadins mimic the effects of cyclic bastadins on calcium homeostasis in cultured neurons.

Elzbieta Zieminska1, Jerzy W Lazarewicz, Elias A Couladouros, Vassilios I Moutsos, Emmanuel N Pitsinos.   

Abstract

Constraining the catechol aryl ether moiety of bastadins by incorporation into a macrocyle is not necessary in order to mimic the effects of these marine natural products on neuronal calcium homeostasis. Simple, acyclic analogs that embody the 'western' or 'eastern' parts of bastadins were found to evoke comparable responses with bastadin 5.

Entities:  

Mesh:

Substances:

Year:  2008        PMID: 18851910     DOI: 10.1016/j.bmcl.2008.09.080

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

Review 1.  Natural products as a source of Alzheimer's drug leads.

Authors:  Philip Williams; Analia Sorribas; Melanie-Jayne R Howes
Journal:  Nat Prod Rep       Date:  2010-11-12       Impact factor: 13.423

2.  Unraveling the bastarane and isobastarane oximo amide configurations and associated macrocycle conformations: implications of their influence on bioactivities.

Authors:  Wayne D Inman; Phillip Crews
Journal:  J Nat Prod       Date:  2011-01-07       Impact factor: 4.050

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.