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Literature DB >> 18851577

Reentrant condensation of proteins in solution induced by multivalent counterions.

F Zhang¹, M W A Skoda, R M J Jacobs, S Zorn, R A Martin, C M Martin, G F Clark, S Weggler, A Hildebrandt, O Kohlbacher, F Schreiber.

Abstract

Negatively charged globular proteins in solution undergo a condensation upon adding trivalent counterions between two critical concentrations C and C, C <C. This reentrant condensation behavior above C is caused by short-ranged electrostatic interactions between multivalent cations and acidic residues, mechanistically different from the case of DNA. Small-angle x-ray scattering indicates a short-ranged attraction between counterion-bound proteins near C and C. Monte Carlo simulations (under these strong electrostatic coupling conditions) support an effective inversion of charge on surface side chains through binding of the multivalent counterions.

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Year: 2008 PMID： 18851577 DOI： 10.1103/PhysRevLett.101.148101

Source DB: PubMed Journal: Phys Rev Lett ISSN： 0031-9007 Impact factor: 9.161

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Cited

26 in total

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Journal: Nat Nanotechnol Date: 2009-08-30 Impact factor: 39.213

2. Protein self-diffusion in crowded solutions.

Authors: Felix Roosen-Runge; Marcus Hennig; Fajun Zhang; Robert M J Jacobs; Michael Sztucki; Helmut Schober; Tilo Seydel; Frank Schreiber
Journal: Proc Natl Acad Sci U S A Date: 2011-07-05 Impact factor: 11.205

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4. Predicting Protein-Protein Interactions of Concentrated Antibody Solutions Using Dilute Solution Data and Coarse-Grained Molecular Models.

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6. Biophysical characterization and molecular simulation of electrostatically driven self-association of a single-chain antibody.

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Journal: Protein Sci Date: 2018-05-03 Impact factor: 6.725

Reentrant condensation of proteins in solution induced by multivalent counterions.

1. Self-assembly of soft nanoparticles with tunable patchiness.

2. Protein self-diffusion in crowded solutions.

3. Tuning ion correlations at an electrified soft interface.

4. Predicting Protein-Protein Interactions of Concentrated Antibody Solutions Using Dilute Solution Data and Coarse-Grained Molecular Models.

Review 5. Electrostatic Interactions in Protein Structure, Folding, Binding, and Condensation.

6. Biophysical characterization and molecular simulation of electrostatically driven self-association of a single-chain antibody.

7. Reentrant Phase Transitions and Non-Equilibrium Dynamics in Membraneless Organelles.

8. Reentrant Phase Transition Drives Dynamic Substructure Formation in Ribonucleoprotein Droplets.

9. Effect of Temperature on Re-entrant Condensation of Globular Protein in Presence of Tri-valent Ions.

10. Unfolding of the chromatin fiber driven by overexpression of noninteracting bridging factors.