Literature DB >> 18848564

Rapid loss of dendritic cell and monocyte responses to TLR ligands following venipuncture.

Angela Meier1, Amelia Fisher, Harlyn K Sidhu, Judy J Chang, Tom F Wen, Hendrik Streeck, Galit Alter, Guido Silvestri, Marcus Altfeld.   

Abstract

Blood samples from multiple sites are collected in multicenter trials, and frequently shipped to centralized laboratories for processing and comparable experimental evaluation. It is therefore of crucial interest to assess the preservation of immune cell functions after overnight shipment of whole blood. Here we evaluated the ability of pDCs, mDCs and monocytes to respond to TLR ligands at multiple timepoints following venipuncture as compared to immediate processing. Our results demonstrate a profound impairment of APC function, in particular of IFN-alpha production of pDCs, if whole blood was processed later than 6 h after venipuncture. Overnight shipment or extended rest of whole blood before processing therefore severely compromises the ability of APCs to respond to TLR ligands, and this has to be taken into consideration when designing multicenter trials.

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Year:  2008        PMID： 18848564      PMCID： PMC2613681          DOI： 10.1016/j.jim.2008.09.007

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  17 in total

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