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Literature DB >> 10973450

Shipment impairs lymphocyte proliferative responses to microbial antigens.

R A Betensky¹, E Connick, J Devers, A L Landay, M Nokta, S Plaeger, H Rosenblatt, J L Schmitz, F Valentine, D Wara, A Weinberg, H M Lederman.

Abstract

Lymphocyte proliferation assays (LPAs) are widely used to assess T-lymphocyte function of patients with human immunodeficiency virus infection and other primary and secondary immunodeficiency disorders. Since these assays require expertise not readily available at all clinical sites, specimens may be shipped to central labs for testing. We conducted a large multicenter study to evaluate the effects of shipping on assay performance and found significant loss of LPA activity. This may lead to erroneous results for individual subjects and introduce bias into multicenter trials.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2000 PMID： 10973450 PMCID： PMC95951 DOI： 10.1128/CDLI.7.5.759-763.2000

Source DB: PubMed Journal: Clin Diagn Lab Immunol ISSN： 1071-412X

7 in total

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