Literature DB >> 18846586

Reversed chloroquines based on the 3,4-dihydropyrimidin-2(1H)-one scaffold: synthesis and evaluation for antimalarial, beta-haematin inhibition, and cytotoxic activity.

Natasha October1, Nicholas D Watermeyer, Vanessa Yardley, Timothy J Egan, Kanyile Ncokazi, Kelly Chibale.   

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Year:  2008        PMID： 18846586     DOI： 10.1002/cmdc.200800172

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


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  10 in total

Review 1.  Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.

Authors:  Robert L Summers; Megan N Nash; Rowena E Martin
Journal:  Cell Mol Life Sci       Date:  2012-06       Impact factor: 9.261

2.  A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.

Authors:  Igor Opsenica; James C Burnett; Rick Gussio; Dejan Opsenica; Nina Todorović; Charlotte A Lanteri; Richard J Sciotti; Montip Gettayacamin; Nicoletta Basilico; Donatella Taramelli; Jonathan E Nuss; Laura Wanner; Rekha G Panchal; Bogdan A Solaja; Sina Bavari
Journal:  J Med Chem       Date:  2011-01-25       Impact factor: 7.446

3.  2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.

Authors:  Kamaljit Singh; Hardeep Kaur; Kelly Chibale; Jan Balzarini; Susan Little; Prasad V Bharatam
Journal:  Eur J Med Chem       Date:  2012-03-13       Impact factor: 6.514

4.  Reversal agent and linker variants of reversed chloroquines: activities against Plasmodium falciparum.

Authors:  Simeon Andrews; Steven J Burgess; Deborah Skaalrud; Jane Xu Kelly; David H Peyton
Journal:  J Med Chem       Date:  2010-01-28       Impact factor: 7.446

Review 5.  Reversed chloroquine molecules as a strategy to overcome resistance in malaria.

Authors:  David H Peyton
Journal:  Curr Top Med Chem       Date:  2012       Impact factor: 3.295

6.  Secondary amine-initiated three-component synthesis of 3,4-dihydropyrimidinones and thiones involving alkynes, aldehydes and thiourea/urea.

Authors:  Jie-Ping Wan; Yunfang Lin; Kaikai Hu; Yunyun Liu
Journal:  Beilstein J Org Chem       Date:  2014-01-29       Impact factor: 2.883

7.  Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery.

Authors:  John Okombo; Kelly Chibale
Journal:  Acc Chem Res       Date:  2017-06-21       Impact factor: 22.384

8.  Synthesis, crystal structure and antibacterial studies of dihydropyrimidines and their regioselectively oxidized products.

Authors:  Alakbar E Huseynzada; Christian Jelch; Haji Vahid N Akhundzada; Sarra Soudani; Cherif Ben Nasr; Aygun Israyilova; Filippo Doria; Ulviyya A Hasanova; Rana F Khankishiyeva; Mauro Freccero
Journal:  RSC Adv       Date:  2021-02-03       Impact factor: 3.361

9.  Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria.

Authors:  Milica Videnović; Dejan M Opsenica; James C Burnett; Laura Gomba; Jonathan E Nuss; Zivota Selaković; Jelena Konstantinović; Maja Krstić; Sandra Segan; Mario Zlatović; Richard J Sciotti; Sina Bavari; Bogdan A Solaja
Journal:  J Med Chem       Date:  2014-05-01       Impact factor: 7.446

Review 10.  Dual-functioning antimalarials that inhibit the chloroquine-resistance transporter.

Authors:  Timothy J Egan; David Kuter
Journal:  Future Microbiol       Date:  2013-04       Impact factor: 3.165
  10 in total

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