BACKGROUND: Pathologic differences have been reported among breast tumors when comparing ethnic populations. Limited research has been done to evaluate the ethnic-specific relationships between breast cancer risk factors and the pathologic features of breast tumors. METHODS: Given that genetic variation may contribute to ethnic-related etiologic differences in breast cancer, we hypothesized that tumor characteristics differ according to family history of breast cancer among Hispanic and non-Hispanic White (NHW) women. Logistic regression models were used to compute odds ratios (OR) and 95% confidence intervals (95% CI) to assess this relationship in the population-based, case-control 4-Corners Breast Cancer Study (1,537 cases and 2,452 controls). RESULTS: Among Hispanic women, having a family history was associated with a 2.7-fold increased risk of estrogen receptor (ER) negative (95% CI, 1.59-4.44), but not ER positive tumors (OR, 1.04; 95% CI, 0.71-1.54) when compared with women without breast cancer. In contrast, there was an increased risk for ER positive (OR, 1.89; 95% CI, 1.50-2.38) and a marginally significant increased risk for ER negative tumors (OR, 1.41; 95% CI, 0.92-2.17) among NHW women. When comparing tumor characteristics among invasive cases, those with a family history also had a significantly higher proportion of ER negative tumors among Hispanics (39.2% versus 25.8%; P=0.02), but not among NHWs (16.3% versus 21.1%; P=0.13). CONCLUSIONS: These results may reflect ethnic-specific predisposing genetic factors that promote the development of specific breast tumor subtypes, and emphasize the importance of evaluating the relationship between breast cancer risk factors and breast tumor subtypes among different ethnic populations.
BACKGROUND: Pathologic differences have been reported among breast tumors when comparing ethnic populations. Limited research has been done to evaluate the ethnic-specific relationships between breast cancer risk factors and the pathologic features of breast tumors. METHODS: Given that genetic variation may contribute to ethnic-related etiologic differences in breast cancer, we hypothesized that tumor characteristics differ according to family history of breast cancer among Hispanic and non-Hispanic White (NHW) women. Logistic regression models were used to compute odds ratios (OR) and 95% confidence intervals (95% CI) to assess this relationship in the population-based, case-control 4-Corners Breast Cancer Study (1,537 cases and 2,452 controls). RESULTS: Among Hispanic women, having a family history was associated with a 2.7-fold increased risk of estrogen receptor (ER) negative (95% CI, 1.59-4.44), but not ER positive tumors (OR, 1.04; 95% CI, 0.71-1.54) when compared with women without breast cancer. In contrast, there was an increased risk for ER positive (OR, 1.89; 95% CI, 1.50-2.38) and a marginally significant increased risk for ER negative tumors (OR, 1.41; 95% CI, 0.92-2.17) among NHW women. When comparing tumor characteristics among invasive cases, those with a family history also had a significantly higher proportion of ER negative tumors among Hispanics (39.2% versus 25.8%; P=0.02), but not among NHWs (16.3% versus 21.1%; P=0.13). CONCLUSIONS: These results may reflect ethnic-specific predisposing genetic factors that promote the development of specific breast tumor subtypes, and emphasize the importance of evaluating the relationship between breast cancer risk factors and breast tumor subtypes among different ethnic populations.
Authors: Roberta McKean-Cowdin; Heather Spencer Feigelson; Lucy Y Xia; Celeste Leigh Pearce; Duncan C Thomas; Daniel O Stram; Brian E Henderson Journal: Hum Genet Date: 2005-02-23 Impact factor: 4.132
Authors: Betsy Risendal; Lisa M Hines; Carol Sweeney; Martha L Slattery; Anna R Giuliano; Kathy B Baumgartner; Karen Curtin; Tim E Byers Journal: Cancer Causes Control Date: 2008-09-26 Impact factor: 2.506
Authors: Esther M John; Alexander Miron; Gail Gong; Amanda I Phipps; Anna Felberg; Frederick P Li; Dee W West; Alice S Whittemore Journal: JAMA Date: 2007-12-26 Impact factor: 56.272
Authors: Megan L Welsh; Diana S M Buist; Erin J Aiello Bowles; Melissa L Anderson; Joann G Elmore; Christopher I Li Journal: Breast Cancer Res Treat Date: 2008-04-25 Impact factor: 4.872
Authors: Lisa M Hines; Betsy Risendal; Tim Byers; Sarah Mengshol; Jan Lowery; Meenakshi Singh Journal: J Womens Health (Larchmt) Date: 2011-07-01 Impact factor: 2.681
Authors: Nasim Mavaddat; Paul D Pharoah; Fiona Blows; Kristy E Driver; Elena Provenzano; Deborah Thompson; Robert J Macinnis; Mitul Shah; Douglas F Easton; Antonis C Antoniou Journal: Breast Cancer Res Date: 2010-02-10 Impact factor: 6.466
Authors: Dongyan Yang; Richard N Baumgartner; Martha L Slattery; Chenxi Wang; Anna R Giuliano; Maureen A Murtaugh; Betsy C Risendal; Tim Byers; Kathy B Baumgartner Journal: PLoS One Date: 2013-02-11 Impact factor: 3.240
Authors: Carmen M Redondo; Manuela Gago-Domínguez; Sara Miranda Ponte; Manuel Enguix Castelo; Xuejuan Jiang; Ana Alonso García; Maite Peña Fernández; María Ausencia Tomé; Máximo Fraga; Francisco Gude; María Elena Martínez; Víctor Muñoz Garzón; Ángel Carracedo; J Esteban Castelao Journal: PLoS One Date: 2012-07-11 Impact factor: 3.240