Literature DB >> 18842099

Blockade of alpha6-integrin reveals diversity in homing patterns among human, baboon, and murine cells.

Halvard Bonig1, Gregory V Priestley, Martin Wohlfahrt, Hans-Peter Kiem, Thalia Papayannopoulou.   

Abstract

Our understanding of the mechanisms by which intravenously transplanted hematopoietic stem/progenitor cells (HSPCs) home to and engraft the bone marrow (BM) remains incomplete, but participation of adhesion molecules has been documented. We here demonstrate that blockade of the alpha6-integrin enhanced BM homing of human and nonhuman primate BM-derived HSPCs by >60% in the xenogeneic transplant model and led to significantly improved engraftment. The effect was limited to BM-derived HSPCs, as granulocyte-colony-stimulating factor mobilized peripheral blood or cord blood HSPCs express little or no alpha6 integrin. By contrast, despite high alpha6 integrin expression, no effect of alpha6 blockade on murine BM-HSPCs homing/engraftment was observed.

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Year:  2009        PMID： 18842099      PMCID： PMC2866506          DOI： 10.1089/scd.2008.0269

Source DB:  PubMed          Journal:  Stem Cells Dev        ISSN： 1547-3287            Impact factor:   3.272


  30 in total

1.  Changes in integrin expression are associated with altered homing properties of Lin(-/lo)Thy1.1(lo)Sca-1(+)c-kit(+) hematopoietic stem cells following mobilization by cyclophosphamide/granulocyte colony-stimulating factor.

Authors:  Amy J Wagers; Richard C Allsopp; Irving L Weissman
Journal:  Exp Hematol       Date:  2002-02       Impact factor: 3.084

2.  Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins.

Authors:  T Papayannopoulou; G V Priestley; B Nakamoto; V Zafiropoulos; L M Scott
Journal:  Blood       Date:  2001-10-15       Impact factor: 22.113

3.  Ex vivo manipulation of umbilical cord blood-derived hematopoietic stem/progenitor cells with recombinant human stem cell factor can up-regulate levels of homing-essential molecules to increase their transmigratory potential.

Authors:  Yizhou Zheng; Nobukazu Watanabe; Tokiko Nagamura-Inoue; Koichi Igura; Hitomi Nagayama; Arinobu Tojo; Ryuji Tanosaki; Yoichi Takaue; Shinichiro Okamoto; Tsuneo A Takahashi
Journal:  Exp Hematol       Date:  2003-12       Impact factor: 3.084

Review 4.  Bone marrow homing: the players, the playfield, and their evolving roles.

Authors:  Thalia Papayannopoulou
Journal:  Curr Opin Hematol       Date:  2003-05       Impact factor: 3.284

5.  Distinct roles of integrins alpha6 and alpha4 in homing of fetal liver hematopoietic stem and progenitor cells.

Authors:  Hong Qian; Elisabeth Georges-Labouesse; Alexander Nyström; Anna Domogatskaya; Karl Tryggvason; Sten Eirik W Jacobsen; Marja Ekblom
Journal:  Blood       Date:  2007-06-22       Impact factor: 22.113

6.  A highly sensitive strategy for SCID-repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD/SCID mice bone marrow.

Authors:  Takashi Yahata; Kiyoshi Ando; Tadayuki Sato; Hiroko Miyatake; Yoshihiko Nakamura; Yukari Muguruma; Shunichi Kato; Tomomitsu Hotta
Journal:  Blood       Date:  2002-10-31       Impact factor: 22.113

7.  Kinetics of in vivo homing and recruitment into cycle of hematopoietic cells are organ-specific but CD44-independent.

Authors:  R A Oostendorp; S Ghaffari; C J Eaves
Journal:  Bone Marrow Transplant       Date:  2000-09       Impact factor: 5.483

8.  In vivo roles of integrins during leukocyte development and traffic: insights from the analysis of mice chimeric for alpha 5, alpha v, and alpha 4 integrins.

Authors:  A G Arroyo; D Taverna; C A Whittaker; U G Strauch; B L Bader; H Rayburn; D Crowley; C M Parker; R O Hynes
Journal:  J Immunol       Date:  2000-10-15       Impact factor: 5.422

9.  Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells.

Authors:  Yu-Chen Gu; Jarkko Kortesmaa; Karl Tryggvason; Jenny Persson; Peter Ekblom; Sten-Eirik Jacobsen; Marja Ekblom
Journal:  Blood       Date:  2002-09-19       Impact factor: 22.113

10.  Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins.

Authors:  Y Kikkawa; N Sanzen; H Fujiwara; A Sonnenberg; K Sekiguchi
Journal:  J Cell Sci       Date:  2000-03       Impact factor: 5.285
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  5 in total

Review 1.  Molecular mechanisms underlying adhesion and migration of hematopoietic stem cells.

Authors:  Aysegul Ocal Sahin; Miranda Buitenhuis
Journal:  Cell Adh Migr       Date:  2012 Jan-Feb       Impact factor: 3.405

Review 2.  Adhesion receptors involved in HSC and early-B cell interactions with bone marrow microenvironment.

Authors:  Maria De Grandis; Anne-Catherine Lhoumeau; Stéphane J C Mancini; Michel Aurrand-Lions
Journal:  Cell Mol Life Sci       Date:  2016-02       Impact factor: 9.261

Review 3.  Progress and obstacles towards generating hematopoietic stem cells from pluripotent stem cells.

Authors:  Jungmin Lee; Brad Dykstra; Robert Sackstein; Derrick J Rossi
Journal:  Curr Opin Hematol       Date:  2015-07       Impact factor: 3.284

Review 4.  The ins and outs of hematopoietic stem cells: studies to improve transplantation outcomes.

Authors:  Leah A Marquez-Curtis; A Robert Turner; Santhi Sridharan; Mariusz Z Ratajczak; Anna Janowska-Wieczorek
Journal:  Stem Cell Rev Rep       Date:  2011-09       Impact factor: 5.739

5.  Integrin αIIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta.

Authors:  Jean-Charles Boisset; Thomas Clapes; Reinier Van Der Linden; Elaine Dzierzak; Catherine Robin
Journal:  Biol Open       Date:  2013-04-11       Impact factor: 2.422
  5 in total

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