PURPOSE OF REVIEW: Triple-negative breast cancer has been of great interest to oncologists because these cancers do not benefit from hormonal therapies or treatments targeted against human epidermal growth factor receptor 2 receptors. The only systemic therapy currently available is chemotherapy, and prognosis remains poor. We would like to describe recent pathological and genetic advancements and their possible implications on the development of new treatment strategies. RECENT FINDINGS: Increasing pathological and molecular knowledge has led to a better understanding of breast cancer in general. Triple-negative breast cancer, however, remains a heterogeneous subgroup with difficult-to-define subtypes. New targeted therapies are currently being developed and researched. SUMMARY: The recent advances in pathological and molecular knowledge have changed the landscape of breast cancer, with triple-negative breast cancer emerging as a pathological and clinical heterogeneous group. The main challenge lies in the development of new tailored treatment strategies for the various subgroups, with receptor kinase inhibition as the most promising new evolution to date. Further trials are needed to validate these new treatment options.
PURPOSE OF REVIEW: Triple-negative breast cancer has been of great interest to oncologists because these cancers do not benefit from hormonal therapies or treatments targeted against human epidermal growth factor receptor 2 receptors. The only systemic therapy currently available is chemotherapy, and prognosis remains poor. We would like to describe recent pathological and genetic advancements and their possible implications on the development of new treatment strategies. RECENT FINDINGS: Increasing pathological and molecular knowledge has led to a better understanding of breast cancer in general. Triple-negative breast cancer, however, remains a heterogeneous subgroup with difficult-to-define subtypes. New targeted therapies are currently being developed and researched. SUMMARY: The recent advances in pathological and molecular knowledge have changed the landscape of breast cancer, with triple-negative breast cancer emerging as a pathological and clinical heterogeneous group. The main challenge lies in the development of new tailored treatment strategies for the various subgroups, with receptor kinase inhibition as the most promising new evolution to date. Further trials are needed to validate these new treatment options.
Authors: Franca Podo; Lutgarde M C Buydens; Hadassa Degani; Riet Hilhorst; Edda Klipp; Ingrid S Gribbestad; Sabine Van Huffel; Hanneke W M van Laarhoven; Jan Luts; Daniel Monleon; Geert J Postma; Nicole Schneiderhan-Marra; Filippo Santoro; Hans Wouters; Hege G Russnes; Therese Sørlie; Elda Tagliabue; Anne-Lise Børresen-Dale Journal: Mol Oncol Date: 2010-04-24 Impact factor: 6.603
Authors: Christian T Evensen; Kathleen J Yost; San Keller; Neeraj K Arora; Elizabeth Frentzel; Tamika Cowans; Steven A Garfinkel Journal: J Oncol Pract Date: 2019-08-19 Impact factor: 3.840
Authors: Andrew R Burke; Ravi N Singh; David L Carroll; James C S Wood; Ralph B D'Agostino; Pulickel M Ajayan; Frank M Torti; Suzy V Torti Journal: Biomaterials Date: 2012-01-14 Impact factor: 12.479
Authors: Aditi Banerjee; Juan A Martinez; Maria O Longas; Zhenbo Zhang; Jesus Santiago; Krishna Baksi; Dipak K Banerjee Journal: Adv Exp Med Biol Date: 2015 Impact factor: 2.622
Authors: He Zhu; Feriyl Bhaijee; Nivin Ishaq; Dominique J Pepper; Kandis Backus; Alexandra S Brown; Xinchun Zhou; Lucio Miele Journal: Am J Cancer Res Date: 2013-04-03 Impact factor: 6.166