Literature DB >> 1883875

Localization of transforming growth factor-beta 1 in mitochondria of murine heart and liver.

U I Heine1, J K Burmester, K C Flanders, D Danielpour, E F Munoz, A B Roberts, M B Sporn.   

Abstract

Using both electron microscopic immunohistochemistry and cell fractionation techniques, we show that transforming growth factor-beta 1 (TGF-beta 1) is found in mitochondria of rat and mouse cardiac myocytes and rat hepatocytes. Four different polyclonal antibodies, raised against various epitopes encompassing the mature portion of the TGF-beta 1 molecule as well as the pro-region of its precursor, were used for the electron microscopy studies. The localization of TGF-beta 1 in mitochondria was confirmed by detection of the native peptide in mitochondria isolated from rat heart and liver; the majority of native TGF-beta 1 found in liver homogenates was recovered in highly pure mitochondrial fractions. The functional role of TGF-beta in the mitochondrion is unknown at present.

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Year:  1991        PMID： 1883875      PMCID： PMC361831          DOI： 10.1091/mbc.2.6.467

Source DB:  PubMed          Journal:  Cell Regul        ISSN： 1044-2030


  25 in total

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Authors:  D Danielpour; K Y Kim; L L Dart; S Watanabe; A B Roberts; M B Sporn
Journal:  Growth Factors       Date:  1989       Impact factor: 2.511

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Journal:  J Cell Biol       Date:  1962-10       Impact factor: 10.539
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  20 in total

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2.  The efficiency of protein compartmentalization into the secretory pathway.

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9.  The alpha-smooth muscle actin-positive cells in healing human myocardial scars.

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