Literature DB >> 18838102

The aging male hypothalamic-pituitary-gonadal axis: pulsatility and feedback.

Johannes D Veldhuis1, Daniel M Keenan, Peter Y Liu, Ali Iranmanesh, Paul Y Takahashi, Ajay X Nehra.   

Abstract

Aging results in insidious decremental changes in hypothalamic, pituitary and gonadal function. The foregoing three main anatomic loci of control are regulated by intermittent time-delayed signal exchange, principally via gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH) and testosterone/estradiol (Te/E(2)). A mathematical framework is required to embody these dynamics. The present review highlights integrative adaptations in the aging male hypothalamic-pituitary-gonadal axis, as assessed by recent objective ensemble models of the axis as a whole.

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Year:  2008        PMID： 18838102      PMCID： PMC2662347          DOI： 10.1016/j.mce.2008.09.005

Source DB:  PubMed          Journal:  Mol Cell Endocrinol        ISSN： 0303-7207            Impact factor:   4.102


  65 in total

1.  Impact of pulsatility on the ensemble orderliness (approximate entropy) of neurohormone secretion.

Authors:  J D Veldhuis; M L Johnson; O L Veldhuis; M Straume; S M Pincus
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2001-12       Impact factor: 3.619

2.  Unequal impact of short-term testosterone repletion on the somatotropic axis of young and older men.

Authors:  A Gentili; T Mulligan; M Godschalk; J Clore; J Patrie; A Iranmanesh; J D Veldhuis
Journal:  J Clin Endocrinol Metab       Date:  2002-02       Impact factor: 5.958

3.  Approximate entropy as a measure of system complexity.

Authors:  S M Pincus
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

4.  Age and testosterone feedback jointly control the dose-dependent actions of gonadotropin-releasing hormone in healthy men.

Authors:  Johannes D Veldhuis; Ali Iranmanesh; Thomas Mulligan
Journal:  J Clin Endocrinol Metab       Date:  2004-10-19       Impact factor: 5.958

Review 5.  Mechanisms of hypoandrogenemia in healthy aging men.

Authors:  Peter Y Liu; Ali Iranmanesh; Ajay X Nehra; Daniel M Keenan; Johannes D Veldhuis
Journal:  Endocrinol Metab Clin North Am       Date:  2005-12       Impact factor: 4.741

6.  Influence of antiopioids on luteinizing hormone pulsatility in aging men.

Authors:  A Vermeulen; J P Deslypere; J M Kaufman
Journal:  J Clin Endocrinol Metab       Date:  1989-01       Impact factor: 5.958

7.  Anterior pituitary luteinizing hormone secretion during continuous perifusion in aging male rats.

Authors:  L W Kaler; V Critchlow
Journal:  Mech Ageing Dev       Date:  1984 Apr-May       Impact factor: 5.432

8.  A biomathematical model of time-delayed feedback in the human male hypothalamic-pituitary-Leydig cell axis.

Authors:  D M Keenan; J D Veldhuis
Journal:  Am J Physiol       Date:  1998-07

9.  Interleukin-1 inhibits Leydig cell steroidogenesis primarily by decreasing 17 alpha-hydroxylase/C17-20 lyase cytochrome P450 expression.

Authors:  D B Hales
Journal:  Endocrinology       Date:  1992-11       Impact factor: 4.736

10.  Progenitor cells of the testosterone-producing Leydig cells revealed.

Authors:  Michail S Davidoff; Ralf Middendorff; Grigori Enikolopov; Dieter Riethmacher; Adolf F Holstein; Dieter Müller
Journal:  J Cell Biol       Date:  2004-11-29       Impact factor: 10.539
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  23 in total

1.  Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men.

Authors:  J T George; J D Veldhuis; A K Roseweir; C L Newton; E Faccenda; R P Millar; R A Anderson
Journal:  J Clin Endocrinol Metab       Date:  2011-06-01       Impact factor: 5.958

Review 2.  Omental transplantation for neuroendocrinological disorders.

Authors:  Hernando Rafael
Journal:  Am J Neurodegener Dis       Date:  2015-09-10

Review 3.  Effects of aging on the male reproductive system.

Authors:  Sezgin Gunes; Gulgez Neslihan Taskurt Hekim; Mehmet Alper Arslan; Ramazan Asci
Journal:  J Assist Reprod Genet       Date:  2016-02-11       Impact factor: 3.412

4.  Improved early postnatal nutrition and its effect on histomorphological parameters in the testes of Sanjabi ram lambs.

Authors:  Aliasghar Moghaddam; Mohammad Panah; Manochehr Souri
Journal:  Trop Anim Health Prod       Date:  2019-02-13       Impact factor: 1.559

5.  Ultradian rhythmicity and induced changes in salivary testosterone.

Authors:  C Martyn Beaven; John R Ingram; Nicholas D Gill; Will G Hopkins
Journal:  Eur J Appl Physiol       Date:  2010-05-29       Impact factor: 3.078

Review 6.  GnRH pulsatility, the pituitary response and reproductive dysfunction.

Authors:  Rie Tsutsumi; Nicholas J G Webster
Journal:  Endocr J       Date:  2009-07-17       Impact factor: 2.349

7.  Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives.

Authors:  Mikhail V Blagosklonny
Journal:  Aging (Albany NY)       Date:  2010-05       Impact factor: 5.682

8.  Hormone secretion by pituitary adenomas is characterized by increased disorderliness and spikiness but more regular pulsing.

Authors:  Ferdinand Roelfsema; Alberto M Pereira; Nienke R Biermasz; Johannes D Veldhuis
Journal:  J Clin Endocrinol Metab       Date:  2014-07-11       Impact factor: 5.958

9.  Hypogonadism in aged hospitalized male patients: prevalence and clinical outcome.

Authors:  P Iglesias; F Prado; M C Macías; M T Guerrero; A Muñoz; E Ridruejo; P Tajada; C García-Arévalo; J J Díez
Journal:  J Endocrinol Invest       Date:  2014-01-09       Impact factor: 4.256

10.  Associations between gonadotropins, testosterone and β amyloid in men at risk of Alzheimer's disease.

Authors:  G Verdile; S M Laws; D Henley; D Ames; A I Bush; K A Ellis; N G Faux; V B Gupta; Q-X Li; C L Masters; K E Pike; C C Rowe; C Szoeke; K Taddei; V L Villemagne; R N Martins
Journal:  Mol Psychiatry       Date:  2012-10-23       Impact factor: 15.992
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