BACKGROUND: The majority of studies have reported risks of breast cancer (BC) from benign breast disease (BBD) in essentially homogenous Caucasian populations. Information on breast cancer risk factors in larger, multi-ethnic populations should facilitate the development of appropriate and targeted risk reduction strategies. DESIGN: Cases and controls were drawn from a parent BBD cohort of 4,970 women, 1,341 African-Americans (AA) and 3,629 non-AA who were diagnosed with BBD after examination of an excisional breast biopsy. Risk factors (34 variables) included demographics, lesion types, and epidemiological variables. RESULTS: The final multivariable model retained significance (P < 0.05) for lesion risk-level, fibroadenoma, and the interaction of age-by-race. Women with proliferative lesions (no atypia, risk level 2) were 1.7 times more likely to develop BC when compared with women with non-proliferative lesions (OR = 1.7, 95% CI 1.13, 2.42, P = 0.009). Women with atypia (risk level 3) were 3.75 times more likely to develop BC compared to women with non-proliferative lesions (OR = 3.75, 95% CI 1.99, 7.06, P < 0.001). The odds of breast cancer was approximately 35% lower among women with fibroadenoma as compared to women without fibroadenoma (OR = 0.65, 95% CI 0.46, 0.94, P = 0.020). AA women with BBD who were 50 years or older were 2.28 times more likely to develop breast cancer as compared to non-AA women who were less than 50 years old (OR = 2.28, 95% CI 1.34, 3.88, P = 0.002). CONCLUSION: Women with fibroadenoma (nonproliferative or proliferative) were less likely to progress to BC. Older AA women are at greater risk for progression to breast cancer from BBD.
BACKGROUND: The majority of studies have reported risks of breast cancer (BC) from benign breast disease (BBD) in essentially homogenous Caucasian populations. Information on breast cancer risk factors in larger, multi-ethnic populations should facilitate the development of appropriate and targeted risk reduction strategies. DESIGN: Cases and controls were drawn from a parent BBD cohort of 4,970 women, 1,341 African-Americans (AA) and 3,629 non-AA who were diagnosed with BBD after examination of an excisional breast biopsy. Risk factors (34 variables) included demographics, lesion types, and epidemiological variables. RESULTS: The final multivariable model retained significance (P < 0.05) for lesion risk-level, fibroadenoma, and the interaction of age-by-race. Women with proliferative lesions (no atypia, risk level 2) were 1.7 times more likely to develop BC when compared with women with non-proliferative lesions (OR = 1.7, 95% CI 1.13, 2.42, P = 0.009). Women with atypia (risk level 3) were 3.75 times more likely to develop BC compared to women with non-proliferative lesions (OR = 3.75, 95% CI 1.99, 7.06, P < 0.001). The odds of breast cancer was approximately 35% lower among women with fibroadenoma as compared to women without fibroadenoma (OR = 0.65, 95% CI 0.46, 0.94, P = 0.020). AA women with BBD who were 50 years or older were 2.28 times more likely to develop breast cancer as compared to non-AA women who were less than 50 years old (OR = 2.28, 95% CI 1.34, 3.88, P = 0.002). CONCLUSION:Women with fibroadenoma (nonproliferative or proliferative) were less likely to progress to BC. Older AA women are at greater risk for progression to breast cancer from BBD.
Authors: Jingfang Cheng; Shijing Qiu; Usha Raju; Sandra R Wolman; Maria J Worsham Journal: Breast Cancer Res Treat Date: 2007-10-05 Impact factor: 4.872
Authors: C Markopoulos; E Kouskos; D Mantas; K Kontzoglou; K Antonopoulou; Z Revenas; V Kyriakou Journal: Eur J Gynaecol Oncol Date: 2004 Impact factor: 0.196
Authors: Asma Ghafoor; Ahmedin Jemal; Elizabeth Ward; Vilma Cokkinides; Robert Smith; Michael Thun Journal: CA Cancer J Clin Date: 2003 Nov-Dec Impact factor: 508.702
Authors: Marvella E Ford; Deanna D Hill; Angela Blount; John Morrison; Maria Worsham; Suzanne L Havstad; Christine Cole Johnson Journal: Oncol Nurs Forum Date: 2002-06 Impact factor: 2.172
Authors: Chae Jung Park; Eun-Kyung Kim; Ha Young Woo; Hee Jung Moon; Jung Hyun Yoon; Min Jung Kim Journal: J Breast Cancer Date: 2015-09-24 Impact factor: 3.588
Authors: Geoffrey C Kabat; Joan G Jones; Neal Olson; Abdissa Negassa; Catherine Duggan; Mindy Ginsberg; Rita A Kandel; Andrew G Glass; Thomas E Rohan Journal: Cancer Causes Control Date: 2010-01-19 Impact factor: 2.506
Authors: Geoffrey C Kabat; Joan G Jones; Neal Olson; Abdissa Negassa; Catherine Duggan; Mindy Ginsberg; Rita A Kandel; Andrew G Glass; Thomas E Rohan Journal: Cancer Epidemiol Date: 2010-01-15 Impact factor: 2.984
Authors: Michele L Cote; Julie J Ruterbusch; Barra Alosh; Sudeshna Bandyopadhyay; Elizabeth Kim; Bassam Albashiti; Bashar Sharaf Aldeen; Derek C Radisky; Marlene H Frost; Daniel W Visscher; Lynn C Hartmann; Warzecha Hind Nassar; Rouba Ali-Femhi Journal: Cancer Prev Res (Phila) Date: 2012-10-19
Authors: Lisa A Newman; Azadeh Stark; Dhanajay Chitale; Margaret Pepe; Gary Longton; Maria J Worsham; S David Nathanson; Patricia Miller; Jessica M Bensenhaver; Erica Proctor; Monique Swain; Christos Patriotis; Paul F Engstrom Journal: JAMA Oncol Date: 2017-08-01 Impact factor: 31.777
Authors: Tehillah S Menes; Karla Kerlikowske; Jane Lange; Shabnam Jaffer; Robert Rosenberg; Diana L Miglioretti Journal: JAMA Oncol Date: 2017-01-01 Impact factor: 31.777