Literature DB >> 18836005

Secretion of insulinotropic proteins by commensal bacteria: rewiring the gut to treat diabetes.

Faping Duan1, Katherine L Curtis, John C March.   

Abstract

Here, we show that commensal bacteria can stimulate intestinal epithelial cells to secrete insulin in response to glucose. Commensal strains were engineered to secrete the insulinotropic proteins GLP-1 and PDX-1. Epithelia stimulated by engineered strains and glucose secreted up to 1 ng ml(-1) of insulin with no significant background secretion.

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Year:  2008        PMID： 18836005      PMCID： PMC2592943          DOI： 10.1128/AEM.01019-08

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  14 in total

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Authors:  Shigeru Yoshida; Yoshitaka Kajimoto; Tetsuyuki Yasuda; Hirotaka Watada; Yoshio Fujitani; Hiroshi Kosaka; Takahiro Gotow; Takeshi Miyatsuka; Yutaka Umayahara; Yoshimitsu Yamasaki; Masatsugu Hori
Journal:  Diabetes       Date:  2002-08       Impact factor: 9.461

3.  Insulin-cell penetrating peptide hybrids with improved intestinal absorption efficiency.

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4.  Pancreatic epithelial cells can be converted into insulin-producing cells by GLP-1 in conjunction with virus-mediated gene transfer of pdx-1.

Authors:  Masayuki Koizumi; Ryuichiro Doi; Koji Fujimoto; Daisuke Ito; Eiji Toyoda; Tomohiko Mori; Kazuhiro Kami; Yoshiya Kawaguchi; George K Gittes; Masayuki Imamura
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6.  Interrupting Vibrio cholerae infection of human epithelial cells with engineered commensal bacterial signaling.

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8.  Engineering of the gut commensal bacterium Bacteroides ovatus to produce and secrete biologically active murine interleukin-2 in response to xylan.

Authors:  M D Farrar; T R Whitehead; J Lan; P Dilger; R Thorpe; K T Holland; S R Carding
Journal:  J Appl Microbiol       Date:  2005       Impact factor: 3.772

Review 9.  Biology of incretins: GLP-1 and GIP.

Authors:  Laurie L Baggio; Daniel J Drucker
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10.  Efficient production and secretion of bovine beta-lactoglobulin by Lactobacillus casei.

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  19 in total

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3.  Homologous Quorum Sensing Regulatory Circuit: A Dual-Input Genetic Controller for Modulating Quorum Sensing-Mediated Protein Expression in E. coli.

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Review 4.  From DNA to targeted therapeutics: bringing synthetic biology to the clinic.

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5.  Programmable probiotics for detection of cancer in urine.

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Review 6.  Engineering the gut microbiota to treat chronic diseases.

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Review 7.  Synthetic Biology and the Gut Microbiome.

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8.  Glucose Metabolism by Escherichia coli Inhibits Vibrio cholerae Intestinal Colonization of Zebrafish.

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Journal:  Infect Immun       Date:  2018-11-20       Impact factor: 3.441

9.  Engineered commensal bacteria reprogram intestinal cells into glucose-responsive insulin-secreting cells for the treatment of diabetes.

Authors:  Franklin F Duan; Joy H Liu; John C March
Journal:  Diabetes       Date:  2015-01-27       Impact factor: 9.461

10.  Genetic Circuits in Salmonella typhimurium.

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