Literature DB >> 18830487

Auto-hydroxylation of FIH-1: an Fe(ii), alpha-ketoglutarate-dependent human hypoxia sensor.

Yuan-Han Chen1, Lindsay M Comeaux, Stephen J Eyles, Michael J Knapp.   

Abstract

HIF-asparaginyl hydroxylase (FIH-1) normally couples O(2)-activation to hydroxylation of Asn(803) on the alpha-subunit of the hypoxia-inducible factor (HIFalpha), a key step in pO(2) sensing; in the absence of HIFalpha, O(2)-activation becomes uncoupled, leading to self-hydroxylation at Trp(296) and a purple Fe(iii)-O-Trp chromophore-this alternative reactivity may affect human hypoxia sensing.

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Year:  2008        PMID： 18830487      PMCID： PMC2668816          DOI： 10.1039/b809099h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  17 in total

1.  Alternative reactivity of an alpha-ketoglutarate-dependent iron(II) oxygenase: enzyme self-hydroxylation.

Authors:  A Liu; R Y Ho; L Que; M J Ryle; B S Phinney; R P Hausinger
Journal:  J Am Chem Soc       Date:  2001-05-30       Impact factor: 15.419

2.  Geometric and electronic structure/function correlations in non-heme iron enzymes.

Authors:  E I Solomon; T C Brunold; M I Davis; J N Kemsley; S K Lee; N Lehnert; F Neese; A J Skulan; Y S Yang; J Zhou
Journal:  Chem Rev       Date:  2000-01-12       Impact factor: 60.622

3.  FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity.

Authors:  P C Mahon; K Hirota; G L Semenza
Journal:  Genes Dev       Date:  2001-10-15       Impact factor: 11.361

4.  Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities.

Authors:  J Zhou; W L Kelly; B O Bachmann; M Gunsior; C A Townsend; E I Solomon
Journal:  J Am Chem Soc       Date:  2001-08-01       Impact factor: 15.419

5.  Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response.

Authors:  Sonja A Dames; Maria Martinez-Yamout; Roberto N De Guzman; H Jane Dyson; Peter E Wright
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-16       Impact factor: 11.205

6.  Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha.

Authors:  Steven J Freedman; Zhen-Yu J Sun; Florence Poy; Andrew L Kung; David M Livingston; Gerhard Wagner; Michael J Eck
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-16       Impact factor: 11.205

7.  Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.

Authors:  Kirsty S Hewitson; Luke A McNeill; Madeline V Riordan; Ya-Min Tian; Alex N Bullock; Richard W Welford; Jonathan M Elkins; Neil J Oldham; Shoumo Bhattacharya; Jonathan M Gleadle; Peter J Ratcliffe; Christopher W Pugh; Christopher J Schofield
Journal:  J Biol Chem       Date:  2002-05-31       Impact factor: 5.157

8.  Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.

Authors:  Jonathan M Elkins; Kirsty S Hewitson; Luke A McNeill; Jurgen F Seibel; Imre Schlemminger; Christopher W Pugh; Peter J Ratcliffe; Christopher J Schofield
Journal:  J Biol Chem       Date:  2002-11-21       Impact factor: 5.157

9.  FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.

Authors:  David Lando; Daniel J Peet; Jeffrey J Gorman; Dean A Whelan; Murray L Whitelaw; Richard K Bruick
Journal:  Genes Dev       Date:  2002-06-15       Impact factor: 11.361

10.  Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.

Authors:  Luke A McNeill; Kirsty S Hewitson; Timothy D Claridge; Jürgen F Seibel; Louise E Horsfall; Christopher J Schofield
Journal:  Biochem J       Date:  2002-11-01       Impact factor: 3.857
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  17 in total

1.  In vivo self-hydroxylation of an iron-substituted manganese-dependent extradiol cleaving catechol dioxygenase.

Authors:  Erik R Farquhar; Joseph P Emerson; Kevin D Koehntop; Mark F Reynolds; Milena Trmčić; Lawrence Que
Journal:  J Biol Inorg Chem       Date:  2011-01-30       Impact factor: 3.358

2.  Coordination changes and auto-hydroxylation of FIH-1: uncoupled O2-activation in a human hypoxia sensor.

Authors:  Yuan-Han Chen; Lindsay M Comeaux; Robert W Herbst; Evren Saban; David C Kennedy; Michael J Maroney; Michael J Knapp
Journal:  J Inorg Biochem       Date:  2008-08-08       Impact factor: 4.155

3.  Uncoupled O2-activation in the human HIF-asparaginyl hydroxylase, FIH, does not produce reactive oxygen species.

Authors:  Evren Saban; Shannon C Flagg; Michael J Knapp
Journal:  J Inorg Biochem       Date:  2011-01-21       Impact factor: 4.155

4.  Increased Turnover at Limiting O2 Concentrations by the Thr(387) → Ala Variant of HIF-Prolyl Hydroxylase PHD2.

Authors:  Serap Pektas; Cornelius Y Taabazuing; Michael J Knapp
Journal:  Biochemistry       Date:  2015-04-28       Impact factor: 3.162

Review 5.  Spectroscopic analyses of 2-oxoglutarate-dependent oxygenases: TauD as a case study.

Authors:  Denis A Proshlyakov; John McCracken; Robert P Hausinger
Journal:  J Biol Inorg Chem       Date:  2016-11-03       Impact factor: 3.358

6.  The facial triad in the α-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O2 activation.

Authors:  John A Hangasky; Cornelius Y Taabazuing; Cristina B Martin; Scott J Eron; Michael J Knapp
Journal:  J Inorg Biochem       Date:  2016-10-17       Impact factor: 4.155

7.  The second coordination sphere of FIH controls hydroxylation.

Authors:  Evren Saban; Yuan-Han Chen; John A Hangasky; Cornelius Y Taabazuing; Breanne E Holmes; Michael J Knapp
Journal:  Biochemistry       Date:  2011-05-03       Impact factor: 3.162

8.  O2 Activation by Nonheme FeII α-Ketoglutarate-Dependent Enzyme Variants: Elucidating the Role of the Facial Triad Carboxylate in FIH.

Authors:  Shyam R Iyer; Vanessa D Chaplin; Michael J Knapp; Edward I Solomon
Journal:  J Am Chem Soc       Date:  2018-09-10       Impact factor: 15.419

9.  Inverse solvent isotope effects arising from substrate triggering in the factor inhibiting hypoxia inducible factor.

Authors:  John A Hangasky; Evren Saban; Michael J Knapp
Journal:  Biochemistry       Date:  2013-02-18       Impact factor: 3.162

10.  Protein Flexibility of the α-Ketoglutarate-Dependent Oxygenase Factor-Inhibiting HIF-1: Implications for Substrate Binding, Catalysis, and Regulation.

Authors:  Cristina B Martin; Vanessa D Chaplin; Stephen J Eyles; Michael J Knapp
Journal:  Biochemistry       Date:  2019-09-20       Impact factor: 3.162
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