Literature DB >> 18830464

Synergistic effects in gene delivery-a structure-activity approach to the optimisation of hybrid dendritic-lipidic transfection agents.

Simon P Jones1, Nathan P Gabrielson, Daniel W Pack, David K Smith.   

Abstract

Novel gene delivery agents based on combining cholesterol units with spermine-functionalised dendrons exhibit enhanced transfection ability-we report significant synergistic effects in mixed (hybrid) systems which combine aspects of both main classes of synthetic vectors, i.e., cationic polymers and lipids.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18830464     DOI： 10.1039/b811852c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  From crazy chemists to engaged learners through education.

Authors:  David K Smith
Journal:  Nat Chem       Date:  2011-08-23       Impact factor: 24.427

Review 2.  Dendrimer nanoscaffolds for potential theranostics of prostate cancer with a focus on radiochemistry.

Authors:  Su-Tang Lo; Amit Kumar; Jer-Tsong Hsieh; Xiankai Sun
Journal:  Mol Pharm       Date:  2013-01-24       Impact factor: 4.939

3.  Bisethylnorspermine lipopolyamine as potential delivery vector for combination drug/gene anticancer therapies.

Authors:  Yanmei Dong; Jing Li; Chao Wu; David Oupický
Journal:  Pharm Res       Date:  2010-06-25       Impact factor: 4.200

Review 4.  Supramolecular Self-Associations of Amphiphilic Dendrons and Their Properties.

Authors:  Evgeny Apartsin; Anne-Marie Caminade
Journal:  Chemistry       Date:  2021-10-29       Impact factor: 5.020

5.  Electrostatic binding of polyanions using self-assembled multivalent (SAMul) ligand displays - structure-activity effects on DNA/heparin binding.

Authors:  Loryn E Fechner; Buthaina Albanyan; Vânia M P Vieira; Erik Laurini; Paola Posocco; Sabrina Pricl; David K Smith
Journal:  Chem Sci       Date:  2016-04-18       Impact factor: 9.825
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.