Literature DB >> 18830379

Correlation of macrophage inflammatory protein-2 expression and brain edema in rats after intracerebral hemorrhage.

He Wu1, Yuwei Cong, Dandan Wang, Ruibo Zhao, Jiping Qi.   

Abstract

Brain edema is one of the most frequent and serious complications of intracerebral hemorrhage (ICH), but its underlying mechanism remains largely unknown. In order to understand whether inflammatory mediators released from the blood after cerebral hemorrhage plays a role in brain edema, we investigated the dynamic change of the inflammatory mediator macrophage inflammatory protein-2 (MIP-2) in rat brain after ICH. Our results indicate that the expression of MIP-2 increases 2 hours and peaks 2 days after ICH. The expression of MIP-2 correlates with NF-kappaB activation and brain water content. These results suggest that MIP-2 expression may play an important role in the development of brain edema after ICH in rats.

Entities:  

Keywords:  MIP-2; NF-κB; brain edema; intracerebral hemorrhage

Year:  2008        PMID： 18830379      PMCID： PMC2491385     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  18 in total

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Journal:  J Neuroinflammation       Date:  2005-02-25       Impact factor: 8.322
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  6 in total

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2.  Dynamic changes of inflammatory markers in brain after hemorrhagic stroke in humans: a postmortem study.

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Journal:  Brain Res       Date:  2010-04-24       Impact factor: 3.252

3.  Intracerebral hemorrhage induces monocyte-related gene expression within six hours: Global transcriptional profiling in swine ICH.

Authors:  Kyle B Walsh; Xiang Zhang; Xiaoting Zhu; Eric Wohleb; Daniel Woo; Long Lu; Opeolu Adeoye
Journal:  Metab Brain Dis       Date:  2019-02-22       Impact factor: 3.584

Review 4.  Preclinical and clinical research on inflammation after intracerebral hemorrhage.

Authors:  Jian Wang
Journal:  Prog Neurobiol       Date:  2010-08-14       Impact factor: 11.685

5.  In vivo microdialysis sampling of cytokines from rat hippocampus: comparison of cannula implantation procedures.

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Authors:  Felix Siaw-Debrah; Mark Nyanzu; Haoqi Ni; Xiao Lin; Zhu Xu; Linhui Ruan; Qichuan Zhuge; Lijie Huang
Journal:  Biomed Res Int       Date:  2017-06-18       Impact factor: 3.411
  6 in total

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