| Literature DB >> 20420814 |
He Wu1, Zhiyi Zhang, Xiaoli Hu, Ruibo Zhao, Yuejia Song, Xiang Ban, Jiping Qi, Jian Wang.
Abstract
This histopathologic case-control study was designed to characterize the dynamic changes in protein expression of nuclear factor-kappa B (NF-kappaB)/p65 subunit, macrophage inflammatory protein-2 (MIP-2), and matrix metalloproteinase-9 (MMP-9) in postmortem brains of patients with and without intracerebral hemorrhage (ICH). Thirty-six human brains from patients with ICH and six control brains were included in this study. We found that expression levels of NF-kappaB/p65, MIP-2, and MMP-9 were each upregulated on the injured side of the hippocampus at times ranging from 2h to 5days post-ICH. Interestingly, the expression of all three markers was also upregulated on the uninjured side of the hippocampus and in the cerebellum, although to a lesser extent. These data suggest that inflammation occurs early and persists for several days after ICH in humans and could be involved in the progression of ICH-induced secondary brain damage. Copyright 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20420814 PMCID： PMC2885522 DOI： 10.1016/j.brainres.2010.04.033
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252