Mani N Pavuluri1, John A Sweeney. 1. Center for Cognitive Medicine at the University of Illinois at Chicago, Chicago, IL 60612, USA. mpavuluri@psych.uic.edu
Abstract
OBJECTIVE: To provide an overview of clinical research aiming to develop a mechanistic understanding of brain dysfunction in child psychiatric disorders. METHOD: Technological, conceptual, and translational approaches relevant to the investigation of brain function in pediatric psychiatric illnesses are explored. Research in the area of pediatric bipolar disorder is used as a prototypic model illustrating the use of complementary techniques of functional magnetic neuroimaging and neurocognitive studies to identify abnormalities in neural circuitry function. RESULTS: Studies of bipolar youths indicate impairment in cognitive and affective neural systems and in the interface of these two circuits. This evolving field paves a future pathway for identifying diagnostic biomarkers for the disorder, providing tools for monitoring response to pharmacotherapy, examining illness-associated alterations in developmental trajectory, and facilitating the use of animal research for guiding the development of novel treatment strategies. CONCLUSIONS: Studies of brain function in child psychiatry are establishing a platform of knowledge and methods that offer promise for revolutionizing both models of illness pathophysiology and future diagnostic and therapeutic practice.
OBJECTIVE: To provide an overview of clinical research aiming to develop a mechanistic understanding of brain dysfunction in childpsychiatric disorders. METHOD: Technological, conceptual, and translational approaches relevant to the investigation of brain function in pediatric psychiatric illnesses are explored. Research in the area of pediatric bipolar disorder is used as a prototypic model illustrating the use of complementary techniques of functional magnetic neuroimaging and neurocognitive studies to identify abnormalities in neural circuitry function. RESULTS: Studies of bipolar youths indicate impairment in cognitive and affective neural systems and in the interface of these two circuits. This evolving field paves a future pathway for identifying diagnostic biomarkers for the disorder, providing tools for monitoring response to pharmacotherapy, examining illness-associated alterations in developmental trajectory, and facilitating the use of animal research for guiding the development of novel treatment strategies. CONCLUSIONS: Studies of brain function in child psychiatry are establishing a platform of knowledge and methods that offer promise for revolutionizing both models of illness pathophysiology and future diagnostic and therapeutic practice.
Authors: H Critchley; E Daly; M Phillips; M Brammer; E Bullmore; S Williams; T Van Amelsvoort; D Robertson; A David; D Murphy Journal: Hum Brain Mapp Date: 2000-02 Impact factor: 5.038
Authors: M L Gorno-Tempini; S Pradelli; M Serafini; G Pagnoni; P Baraldi; C Porro; R Nicoletti; C Umità; P Nichelli Journal: Neuroimage Date: 2001-08 Impact factor: 6.556
Authors: J N Giedd; A C Vaituzis; S D Hamburger; N Lange; J C Rajapakse; D Kaysen; Y C Vauss; J L Rapoport Journal: J Comp Neurol Date: 1996-03-04 Impact factor: 3.215
Authors: Brendan A Rich; Mariana Schmajuk; Koraly E Perez-Edgar; Nathan A Fox; Daniel S Pine; Ellen Leibenluft Journal: Am J Psychiatry Date: 2007-02 Impact factor: 18.112
Authors: G Bush; J A Frazier; S L Rauch; L J Seidman; P J Whalen; M A Jenike; B R Rosen; J Biederman Journal: Biol Psychiatry Date: 1999-06-15 Impact factor: 13.382
Authors: S Kristian Hill; Margret S H Harris; Ellen S Herbener; Mani Pavuluri; John A Sweeney Journal: Schizophr Bull Date: 2008-04-29 Impact factor: 9.306
Authors: Mani N Pavuluri; James A Ellis; Ezra Wegbreit; Alessandra M Passarotti; Michael C Stevens Journal: Behav Brain Res Date: 2011-10-08 Impact factor: 3.332
Authors: Ezra Wegbreit; James A Ellis; Aneesh Nandam; Jacklynn M Fitzgerald; Alessandra M Passarotti; Mani N Pavuluri; Michael C Stevens Journal: Brain Connect Date: 2011-12-07